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Practice Guidelines

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Effects of Yoga in Patients with Asthma - Cochrane for Clinicians - American Family ...

Aug 1, 2017 - Regular yoga improves quality of life as measured on the Asthma Quality of Life Questionnaire (mean difference = 0.57 units on a seven-point scale; 95% confidence interval [CI], 0.37 to 0.77); improves asthma symptoms (standardized mean difference = 0.37; 95% CI, 0.09 to 0.65); and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0801/p159.html

Effects of Altered Dietary Salt Intake in Patients with Chronic Kidney Disease - ...

Apr 1, 2017 - Reducing salt intake lowers blood pressure and reduces proteinuria in patients with CKD, but there is no evidence to determine whether lowering salt consumption leads to clinically significant reductions in end-stage renal disease, cardiovascular events, or all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0401/p423.html

Selective Serotonin Reuptake Inhibitors for Fibromyalgia - Cochrane for Clinicians - ...

Oct 1, 2016 - SSRIs may have a small to moderate effect on pain (number needed to treat [NNT] = 10), global improvement (NNT = 7), and depression (NNT = 13) in patients with fibromyalgia, but the quality of evidence is very low because of bias and small studies. SSRIs do not reduce fatigue related to...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1001/p548.html

Chewing Gum for Postoperative Recovery of Gastrointestinal Function - Cochrane for ...

Dec 1, 2015 - Having patients chew gum reduces the time to first flatus and time to first bowel movement, as well as the length of hospitalization by about half a day.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1201/p974.html

Psychological Interventions for Medically Unexplained Physical Symptoms - Cochrane for ...

Dec 1, 2015 - Psychological therapy, specifically cognitive behavior therapy (CBT), has been shown to reduce the severity of medically unexplained physical symptoms in patients with somatoform disorders. The effect is small to moderate in magnitude, but in these studies CBT was as acceptable as usual...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1201/p975.html

The Epley Maneuver for Treatment of Benign Paroxysmal Positional Vertigo - Cochrane for...

Aug 1, 2015 - Treatment with the Epley maneuver resolves benign paroxysmal positional vertigo better than sham therapy or control. Minor adverse effects are uncommon.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0801/p184.html

Tricyclic Antidepressants for the Treatment of ADHD in Children and Adolescents - ...

Sep 1, 2015 - TCAs, specifically desipramine and nortriptyline (Pamelor), are superior to placebo at reducing ADHD symptoms in the short term (two to six weeks); however, the quality of evidence is low. Increased heart rate and diastolic blood pressure may be noted with treatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0901/p352.html

Pharmacologic Therapy for Gastroesophageal Reflux Disease in Children - Cochrane for ...

Sep 1, 2015 - Among infants younger than 12 months diagnosed with GERD, weak evidence supports the use of proton pump inhibitors (PPIs) and histamine H2 antagonists. Among children 12 months and older, studies have shown moderate benefit from PPIs and weak benefit from H2 antagonists for providing ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0901/p351.html

Buprenorphine Maintenance vs. Methadone Maintenance or Placebo for Opioid Use Disorder ...

Feb 1, 2015 - At dosages greater than 2 mg per day, buprenorphine maintains treatment retention better than placebo. When flexible dosing (doses adjusted based on patient symptoms) is used, the effectiveness of buprenorphine is comparable to that of methadone in suppressing opioid use.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p165.html

Intranasal Corticosteroids for Acute Bacterial Sinusitis - Cochrane for Clinicians - ...

Sep 1, 2014 - Compared with patients not treated with intranasal corticosteroids, those who receive them have greater improvement or resolution of symptoms at two to three weeks, regardless of whether antibiotics are used. In a single head-to-head study, patients taking intranasal corticosteroids ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0901/p286.html

Safety of Long-Acting Beta Agonists in Adults with Asthma - Cochrane for Clinicians - ...

Oct 1, 2014 - LABAs appear to be safe when used with inhaled corticosteroids. LABA monotherapy is associated with an increase in asthma-related mortality and nonfatal serious adverse events, but not in all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1001/p453.html

Topiramate for the Prophylaxis of Episodic Migraine in Adults - Cochrane for Clinicians...

Jul 1, 2014 - Topiramate in a dosage of 100 mg per day is effective for decreasing the frequency of headaches in adults with episodic migraine.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0701/p24.html

Antibiotics for Sore Throat - Cochrane for Clinicians - American Family Physician

Jul 1, 2014 - Compared with placebo, antibiotics can shorten the duration of sore throat symptoms by about 16 hours and can reduce complications. In countries where the absolute rates of complications are higher, antibiotic therapy is more likely to be effective. The effectiveness of antibiotic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0701/p23.html

Effectiveness of Calcium Channel Blockers for Raynaud Phenomenon - Cochrane for ...

Aug 1, 2014 - CCBs are modestly effective at reducing the frequency of attacks of primary Raynaud phenomenon. There is no evidence that attack severity or physiologic measurements are reduced by CCBs. Treatment is associated with adverse effects such as headache, flushing, and edema.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0801/p143.html

Corticosteroids for the Treatment of Sore Throat - Cochrane for Clinicians - American ...

Jan 1, 2014 - In adults with suspected bacterial pharyngitis who require antibiotic therapy, adding a corticosteroid may increase the likelihood of complete pain resolution at 24 hours. Further study is needed to assess the safety of corticosteroids and whether they can be recommended for presumed ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0101/p14.html

Optimal Antibiotic Regimen for Treating Lower UTI in Children - Cochrane for Clinicians...

Nov 1, 2013 - For the afebrile child with a UTI, a short course (three to seven days) of antibiotics is as effective at preventing the recurrence of symptomatic UTI as a long course (seven to 10 days). There is no clear evidence of superiority for any one antibiotic regimen.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1101/p577.html

Impact of Industry Sponsorship on Research Outcomes - Cochrane for Clinicians - ...

Dec 1, 2013 - Are research studies sponsored by industry more likely to have favorable results and conclusions than studies without industry sponsorship?

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1201/p746.html

Effect of Cocoa on Blood Pressure - Cochrane for Clinicians - American Family Physician

Apr 1, 2013 - Consuming 50 g of cocoa daily will lower blood pressure 2 to 3 mm Hg on average in adults with hypertension. Evidence of improved patient-oriented outcomes does not exist.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0401/p484.html

Physical Training for Patients with Asthma - Cochrane for Clinicians - American Family ...

Mar 1, 2013 - Physical training lasting for at least 20 to 30 minutes, two to three times a week for at least six weeks, improves physical fitness in patients with asthma. Physical training is not associated with worsening of asthma symptoms, and it improves health-related quality of life.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0301/p313.html

Insulin for Glycemic Control in Acute Ischemic Stroke - Cochrane for Clinicians - ...

Dec 1, 2012 - Administering insulin to maintain glycemic control does not improve the rates of mortality or dependency, or the final neurologic outcome after an acute ischemic stroke. Additionally, in randomized controlled trials, patients in the intervention groups (those under tight glycemic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1201/p1008.html

Amphetamines for Attention-Deficit/Hyperactivity Disorder in Adults - Cochrane for ...

Sep 1, 2012 - Amphetamines improve ADHD symptom severity but, when compared with placebo, they are associated with increased discontinuation rates because of adverse effects. There does not appear to be a difference among dosages or between the immediate- and sustained-release formulations.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0901/p413.html

Nicotine Receptor Partial Agonists for Smoking Cessation - Cochrane for Clinicians - ...

Oct 1, 2011 - Compared with placebo, varenicline more than doubles the chances of successful long-term smoking abstinence. In head-to-head trials, varenicline appears to be at least as effective as nicotine replacement therapy and bupropion (Zyban). The most common adverse effect is nausea, which ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1001/p769.html

Clozapine vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for Clinicians...

Feb 1, 2011 - Although further trials are needed, there is some evidence that clozapine is slightly more effective than risperidone (Risperdal). Fewer participants taking clozapine dropped out of studies because of lack of effectiveness compared with those taking risperidone (number needed to treat =...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0201/p260.html

Preoperative Testing for Patients Undergoing Cataract Surgery - Cochrane for Clinicians...

Dec 1, 2009 - Routine preoperative testing before cataract surgery does not reduce intraoperative or postoperative complications.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/1201/p1228.html

Usefulness of Measuring Antiepileptic Medication Blood Levels in Patients with Epilepsy...

Nov 1, 2010 - When treating a patient for epilepsy, there is not enough evidence to indicate if optimal seizure control is best obtained by routinely measuring medication levels compared with making adjustments based on the clinical picture.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/1101/p1070.html

Aripiprazole vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for ...

Jun 1, 2010 - Aripiprazole is less effective in treating schizophrenia than olanzapine (Zyprexa), but has fewer metabolic and sedative adverse effects. There is no difference in effectiveness between aripiprazole and risperidone (Risperdal); however, aripiprazole may be associated with less dystonia,...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0601/p1335.html

Effectiveness of Antidepressants Compared with Placebo for Depression in Primary Care -...

Jul 1, 2010 - Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0701/p42.html

Risperidone vs. Placebo for Schizophrenia - Cochrane for Clinicians - American Family ...

May 1, 2010 - Compared with placebo, risperidone improves symptoms based on some disease-specific symptom scores for schizophrenia. However, it does not appear to improve symptoms on a more important Clinical Global Impression scale.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0501/p1096.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jul 1, 2009 - Although LMWH appears to be more effective than oral anticoagulants in the prevention of recurrent VTE, this does not translate into a survival benefit. LMWH and oral anticoagulants have the same reported adverse events of bleeding and thrombocytopenia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0701/p30.html

Alendronate for Fracture Prevention in Postmenopause - Cochrane for Clinicians - ...

Sep 1, 2008 - In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0901/p579.html

Cranberry Products for Treatment of Urinary Tract Infection - Cochrane for Clinicians -...

Aug 1, 2008 - Over a 12-month period, cranberry products decrease the incidence of symptomatic urinary tract infections (UTIs), especially in women with recurrent UTIs. Optimal dosage and form of administration (juice, tablets, or capsules) is unclear. There are no studies comparing cranberry juice ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0801/p332.html

Over-the-Counter Medications for Acute Cough Symptoms - Cochrane for Clinicians - ...

Jul 1, 2008 - It is uncertain whether OTC cough medications are effective in reducing cough symptoms in adults; in children, no trials show a statistically significant benefit in the treatment compared with the placebo groups. Overall, the quality of evidence is poor; adult studies show conflicting ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p52.html

Antidepressants to Treat Nonspecific Low Back Pain - Cochrane for Clinicians - American...

Jul 1, 2008 - Although antidepressants have been shown to be superior to placebo in some forms of chronic pain, they do not reduce pain or improve functional status or depression in patients with nonspecific low back pain.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p51.html

Are SSRIs Effective for Treating OCD? - Cochrane for Clinicians - American Family ...

May 1, 2008 - SSRIs are effective for the treatment of OCD. If it is assumed that 10 percent of persons with OCD will recover without treatment, then 12 persons with OCD need to be treated for one additional person to have a response within six to 13 weeks. If it is assumed that 20 percent of persons...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0501/p1252.html

Advance Provision for Emergency Oral Contraception - Cochrane for Clinicians - American...

Sep 1, 2007 - Providing oral emergency contraceptives in advance to fertile women for use after unprotected sexual intercourse (i.e., advance provision) does not affect pregnancy rates, condom use, sexually transmitted infection rates, or type of contraception used. Advance provision more than ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0901/p654.html

Cochrane for Clinicians - Apr 1, 2007 - American Family Physician

Apr 1, 2007 - Topical salicylic or lactic acid and cryotherapy are effective treatments for nongenital warts. Although cryotherapy is somewhat more effective, it is associated with more pain and blistering than salicylic or lactic acid. The spontaneous cure rate of nongenital warts is 50 to 70 ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0401/p1001a.html

Opioids for Management of Breakthrough Pain in Cancer Patients - Cochrane for ...

Dec 1, 2006 - Oral transmucosal fentanyl citrate (OTFC [Actiq]), a rapid-acting opioid, has been shown to be an effective treatment for breakthrough cancer pain. Other opioids, including immediate-release oral morphine (MSIR), also may be effective; however, evidence comparing these agents with OTFC ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1201/p1855.html

Early Invasive Therapy or Conservative Management for Unstable Angina or NSTEMI? - ...

Jan 1, 2007 - Compared with conservative management, early invasive treatment of patients with UA or NSTEMI using coronary angiography with or without revascularization reduces rehospitalization and refractory angina within the first year and significantly reduces mortality and myocardial infarction ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0101/p47.html

Exercises for Mechanical Neck Disorders - Cochrane for Clinicians - American Family ...

Oct 1, 2006 - There is some evidence that a variety of exercises help patients with mechanical neck pain. Evidence is strongest for a multimodal approach that includes exercise and mobilization or manipulation of the cervical spine, although this research has been criticized for having an imperfect ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1001/p1126.html

Laxatives for Hemorrhoids? - Cochrane for Clinicians - American Family Physician

Aug 1, 2006 - Fiber has a consistent beneficial effect in the treatment of symptomatic hemorrhoids for up to three months' follow-up as measured by overall symptoms and bleeding.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0801/p413.html

Cochrane for Clinicians - Jul 1, 2006 - American Family Physician

Jul 1, 2006 - Intravenous lidocaine and oral mexiletine provide a modest reduction in neuropathic pain with no indication of serious adverse effects. However, safety data are limited because most studies were of relatively short duration and fewer than 400 patients have been studied in total for each...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0701/p79.html

Acute Treatment of Hyperkalemia - Cochrane for Clinicians - American Family Physician

Nov 1, 2005 - According to disease-oriented evidence, insulin and intravenous glucose, inhaled albuterol (Ventolin), and dialysis are the best treatment options; the first two may be given in combination. Bicarbonate or resins are not recommended for routine use, particularly without one of the more ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1101/p1703.html

Spinal Manipulative Therapy for Low Back Pain - Cochrane for Clinicians - American ...

Feb 1, 2005 - In the short term, manipulative therapy is as effective for acute or chronic low back pain as other treatments such as analgesics, physical therapy, exercises, back school, and routine care from a primary care physician. Radiation of pain, type of manipulation, and use of multiple ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0201/p464.html

Glucocorticoids for Treatment of Croup - Cochrane for Clinicians - American Family ...

Jan 1, 2005 - Compared with placebo, treatment with glucocorticoids results in reduced symptoms, less need for treatment with racemic epinephrine, fewer readmissions to emergency departments, and shorter hospital stays.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0101/p66.html

Optimal Dosage of Tricyclic Antidepressants - Cochrane for Clinicians - American Family...

Oct 1, 2004 - Although the quality of the data limits the strength of the recommendation, current evidence shows that 75 to 100 mg per day of a tricyclic antidepressant is more effective than placebo. Higher dosages are not more effective and are associated with more dropouts because of side effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1001/p1270.html

Intensive Management of Gestational Diabetes - Cochrane for Clinicians - American ...

Sep 1, 2004 - There is not enough evidence to support dietary or drug treatment in patients with gestational diabetes.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/0901/p866.html

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