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Effectiveness of Antidepressants Compared with Placebo for Depression in Primary Care -...

Jul 1, 2010 - Tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) are more effective than placebo for the treatment of depression in primary care settings.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0701/p42.html

Optimal Dosage of Tricyclic Antidepressants - Cochrane for Clinicians - American Family...

Oct 1, 2004 - Although the quality of the data limits the strength of the recommendation, current evidence shows that 75 to 100 mg per day of a tricyclic antidepressant is more effective than placebo. Higher dosages are not more effective and are associated with more dropouts because of side effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1001/p1270.html

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