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Systemic Sclerosis/Scleroderma: A Treatable Multisystem Disease - American Family ...

Oct 15, 2008 - Systemic sclerosis (systemic scleroderma) is a chronic connective tissue disease of unknown etiology that causes widespread microvascular damage and excessive deposition of collagen in the skin and internal organs. Raynaud phenomenon and scleroderma (hardening of the skin) are hallmarks...

American Family Physician : Article

https://www.aafp.org/afp/2008/1015/p961.html

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