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Genetics - American Family Physician

Jan 1, 2019 - This collection features AFP content on genetics and related issues, including family medical history, genetic testing, and specific syndromes (fetal alcohol spectrum disorders, fragile X syndrome, Down Syndrome, Klinefelter syndrome, Prader-Willi syndrome, Turner syndrome). This ...

American Family Physician : AFP By Topic

https://www.aafp.org/afp/topicModules/viewTopicModule.htm?topicModuleId=56

Opportunities to Improve Outcomes in Sickle Cell Disease - American Family Physician

Jul 15, 2006 - Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The pathophysiology involves abnormalities not just in red blood cells but also vascular endothelium, white blood cell function, coagulation, and inflammatory response. Known sequelae of sickle cell disease ...

American Family Physician : Article

https://www.aafp.org/afp/2006/0715/p303.html

The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse ...

Aug 1, 2007 - Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may ...

American Family Physician : Article

https://www.aafp.org/afp/2007/0801/p391.html

Genetic Test Results That Identify Increased Risk Do Not Change Behavior - POEMs - ...

Jul 15, 2016 - Patients informed via genetic test results that they were at increased risk of disease did not subsequently alter their behaviors. For example, persons at increased risk of diabetes mellitus or hypertension were no more likely to change their diet or increase their physical activity. ...

American Family Physician : POEMs

https://www.aafp.org/afp/2016/0715/p168.html

When to Suspect a Genetic Syndrome - American Family Physician

Nov 1, 2012 - Family physicians should be able to recognize findings on physical examination and history that suggest the presence of a genetic syndrome to aid in the diagnosis and treatment of potentially affected patients, as well as subspecialty referral. General themes that can alert family ...

American Family Physician : Article

https://www.aafp.org/afp/2012/1101/p826.html

Genetic Factors In Drug Metabolism - American Family Physician

Jun 1, 2008 - Patients vary widely in their response to drugs. Having an understanding of the pharmacokinetic and pharmacodynamic properties of various medications is importantwhen assessing ethnic differences in drug response. Genetic factors can account for 20 to 95 percent of patient variability. ...

American Family Physician : Article

https://www.aafp.org/afp/2008/0601/p1553.html

Turner Syndrome: Diagnosis and Management - American Family Physician

Aug 1, 2007 - Turner syndrome occurs in one out of every 2,500 to 3,000 live female births. The syndrome is characterized by the partial or complete absence of one X chromosome (45,X karyotype). Patients with Turner syndrome are at risk of congenital heart defects (e.g., coarctation of aorta, ...

American Family Physician : Article

https://www.aafp.org/afp/2007/0801/p405.html

Is "Precision Medicine" Ready to Use in Primary Care Practice? No: It Is Barely Ready ...

Dec 15, 2017 - Precision medicine is ultimately only a tool, and just as it might be used to facilitate better outcomes, if adopted prematurely, it may paradoxically increase inappropriate care. Therefore, primary care physicians must wait for carefully conducted randomized studies to demonstrate ...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2017/1215/p769.html

Family History: The Three-Generation Pedigree - American Family Physician

Aug 1, 2005 - The collection of a family history ranges from simply asking patients if family members have the same presenting illness to diagramming complex medical and psychosocial relationships as part of a family genogram. The three-generation pedigree provides a pictorial representation of ...

American Family Physician : Article

https://www.aafp.org/afp/2005/0801/p441.html

Practice Guidelines - Apr 15, 2006 - American Family Physician

Apr 15, 2006 - The American College of Obstetricians and Gynecologists (ACOG) has released an opinion statement on issues specific to pregnancy in obese women. Women who are obese are at increased risk of complications of pregnancy such as gestational hypertension and diabetes, preeclampsia, fetal ...

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2006/0415/p1471.html

Primary Care of Infants and Young Children with Down Syndrome - American Family Physician

Jan 15, 1999 - Down syndrome is caused by triplicate material of chromosome 21. The syndrome has a variable physical expression, but congenital cardiac defects, transient myelodysplasia of the newborn and duodenal atresia are highly specific for this chromosomal disorder. Routine health maintenance is...

American Family Physician : Article

https://www.aafp.org/afp/1999/0115/p381.html

Genetic Testing: When to Test, When to Refer - Editorials - American Family Physician

Jul 1, 2005 - ...but most are considerably rarer. The common complex disorders that comprise the bread and butter of primary care, such as breast cancer, hypertension, asthma, and cleft lip, are attributed to the interaction of subtle variations in multiple genes and environmental factors, and they...

American Family Physician : Editorials

https://www.aafp.org/afp/2005/0701/p33.html

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