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ACE Inhibitors vs. ARBs for Patients with Diabetic Kidney Disease - Cochrane for ...

Jul 1, 2007 - Studies comparing ACE inhibitors or ARBs with placebo found no mortality benefit in patients with diabetic kidney disease. A subgroup analysis of five studies (2,034 total patients) found that, when given at full or maximally tolerated doses, ACE inhibitors reduce all-cause mortality ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0701/p68.html

ACE Inhibitors vs. ARBs for Primary Hypertension - Cochrane for Clinicians - American ...

Apr 15, 2015 - ACE inhibitors and ARBs have similar effects on cardiovascular outcomes and total mortality in head-to-head trials. However, slightly more adverse effects were noted in patients assigned to ACE inhibitor therapy.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0415/p522.html

Acetaminophen for the Treatment of Pain in Newborns - Cochrane for Clinicians - ...

Aug 1, 2016 - Acetaminophen does not significantly reduce pain associated with heel lance, eye examinations, or assisted vaginal births in newborns. Acetaminophen may reduce the total amount of morphine a newborn needs in the first 48 hours following major abdominal or thoracic surgery.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0801/p216.html

Aclidinium for Stable COPD - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Aclidinium did not decrease all-cause mortality or exacerbations requiring oral steroids, antibiotics, or both. However, aclidinium decreased the number of patients with exacerbations requiring hospitalization and improved quality of life in those with stable COPD.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p760.html

Acute Treatment of Hyperkalemia - Cochrane for Clinicians - American Family Physician

Nov 1, 2005 - According to disease-oriented evidence, insulin and intravenous glucose, inhaled albuterol (Ventolin), and dialysis are the best treatment options; the first two may be given in combination. Bicarbonate or resins are not recommended for routine use, particularly without one of the more ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1101/p1703.html

Addition of Long-Acting Beta Agonists for Asthma in Children - Cochrane for Clinicians ...

Mar 1, 2010 - In children with persistent asthma who are already taking inhaled corticosteroids, the addition of a LABA does not lower the rate of exacerbations requiring oral steroids, rescue medication, or hospitalizations, but it improves measurable lung function.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0301/p598.html

Adenosine vs. Calcium Channel Blockers for Supraventricular Tachycardia - Cochrane for ...

Jun 1, 2007 - Adenosine and verapamil (Calan, Isoptin SR) are equally effective for treating acute supra-ventricular tachycardia in adults. Patients treated with adenosine have a higher rate of minor, transient adverse effects than patients treated with verapamil; however, rare but serious adverse ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0601/p1653.html

Alendronate for Fracture Prevention in Postmenopause - Cochrane for Clinicians - ...

Sep 1, 2008 - In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0901/p579.html

Alpha Blockers to Speed Ureteral Stone Passage - Cochrane for Clinicians - American ...

Feb 1, 2015 - Compared with patients receiving standard therapy (e.g., fluids, analgesics), placebo, or calcium channel blockers, patients receiving alpha blockers had about three fewer days to ureteral stone expulsion and were less likely to be hospitalized. Adverse effects of alpha blocker therapy ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p164.html

Alternative Interventions for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Men -...

Jun 1, 2019 - In men with chronic pelvic pain and urinary dysfunction who have not responded to standard medical management, extracorporeal shock wave therapy reduces symptoms and increases quality of life. Acupuncture may also provide benefit to some patients.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p677.html

Amiodarone for the Prevention of Sudden Cardiac Death - Cochrane for Clinicians - ...

Nov 1, 2016 - Although not a substitute for an implantable cardioverter-defibrillator (ICD), amiodarone is effective for the primary prevention of sudden cardiac death when compared with placebo (number needed to treat [NNT] = 47; 95% confidence interval [CI], 33 to 100), but it does not ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1101/p692.html

Amphetamines for Attention-Deficit/Hyperactivity Disorder in Adults - Cochrane for ...

Sep 1, 2012 - Amphetamines improve ADHD symptom severity but, when compared with placebo, they are associated with increased discontinuation rates because of adverse effects. There does not appear to be a difference among dosages or between the immediate- and sustained-release formulations.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0901/p413.html

Antibiotics for Acute Laryngitis in Adults - Cochrane for Clinicians - American Family ...

Jul 1, 2005 - Two small trials of antibiotic treatment in acute laryngitis do not support routine use of antibiotics in these patients. Most patients will feel better in five to seven days, and it is unlikely that they will experience a clinically important benefit from antibiotics.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0701/p76.html

Antibiotics for Acute Maxillary Sinusitis - Cochrane for Clinicians - American Family ...

May 1, 2009 - Although there is some evidence that antibiotics are effective in the treatment of acute uncomplicated sinusitis, this benefit is modest. Most patients with acute sinusitis improve within two weeks without antibiotics. The potential risk of adverse effects from antibiotics may outweigh ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0501/p757.html

Antibiotics for Exacerbations of COPD - Cochrane for Clinicians - American Family ...

Sep 1, 2006 - There is consistent evidence from a small number of studies that antibiotics significantly reduce mortality (number needed to treat [NNT] = 8) and treatment failure (NNT = 3) in more severely ill patients with COPD who are hospitalized because of an exacerbation. Two smaller studies ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p749.html

Antibiotics for Recurrent Urinary Tract Infections - Cochrane for Clinicians - American...

Apr 1, 2005 - Prophylactic antibiotics can reduce the number of recurrent UTIs in nonpregnant women while they are taking the medication (relative risk [RR], 0.21; number needed to treat [NNT], 2). No antibiotic was significantly better than others at decreasing the number of UTIs, and all ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0401/p1301.html

Antibiotics for Sore Throat - Cochrane for Clinicians - American Family Physician

Jul 1, 2014 - Compared with placebo, antibiotics can shorten the duration of sore throat symptoms by about 16 hours and can reduce complications. In countries where the absolute rates of complications are higher, antibiotic therapy is more likely to be effective. The effectiveness of antibiotic ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0701/p23.html

Anticholinergic Drugs for Overactive Bladder - Cochrane for Clinicians - American ...

Jan 1, 2006 - Tolterodine (Detrol) is as effective as immediate-release oxybutynin (Ditropan) and causes less dry mouth. A dose of 1 mg tolterodine twice daily is as effective as higher dosages of tolterodine. Extended-release preparations have less risk of dry mouth but are more expensive.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0101/p66.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jun 1, 2019 - Low-molecular-weight heparin (LMWH), vitamin K antagonists, and direct oral anticoagulants, when used to prevent recurrent VTE, have a similar impact on all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0601/p676.html

Anticoagulation for the Long-term Treatment of VTE in Patients with Cancer - Cochrane ...

Jul 1, 2009 - Although LMWH appears to be more effective than oral anticoagulants in the prevention of recurrent VTE, this does not translate into a survival benefit. LMWH and oral anticoagulants have the same reported adverse events of bleeding and thrombocytopenia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0701/p30.html

Anticonvulsant Medications for Migraine Prevention - Cochrane for Clinicians - American...

May 1, 2005 - Good evidence supports the use of anticonvulsants as a class with overall reduction in number of headaches per month and overall increase in patients achieving 50 percent reduction of headache frequency. Of the medications within this heterogeneous group, valproic acid and divalproex ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0501/p1699.html

Antidepressants and Smoking Cessation - Cochrane for Clinicians - American Family ...

Jan 1, 2005 - Bupropion and nortriptyline increase the likelihood of smoking cessation, but selective serotonin reuptake inhibitors (SSRIs) do not.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0101/p67.html

Antidepressants for Agitation and Psychosis in Patients with Dementia - Cochrane for ...

Jan 1, 2012 - There are few high-quality studies examining the effectiveness of antidepressants for treating the neuropsychiatric symptoms of dementia. Although there is some evidence to support the use of the selective serotonin reuptake inhibitors (SSRIs) sertraline (Zoloft) and citalopram ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0101/p20.html

Antidepressants for Generalized Anxiety Disorder - Cochrane for Clinicians - American ...

Nov 1, 2003 - As a group, antidepressants are an effective short-term treatment for GAD. Compared with placebo, about five to six patients must be treated to get one additional patient who responds to therapy. Side effects occur more frequently with antidepressants than with placebo, but they are not...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/1101/p1757.html

Antidepressants for the Treatment of Neuropathic Pain - Cochrane for Clinicians - ...

Jun 1, 2006 - Tricyclic antidepressants, particularly amitriptyline, are effective for the treatment of painful diabetic neuropathy and post herpetic neuralgia, and may be beneficial in other neuropathic pain syndromes, but they should be used with caution in patients at increased risk of adverse ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0601/p1933.html

Antidepressants in Older Persons - Cochrane for Clinicians - American Family Physician

Nov 1, 2006 - In older persons with depression, three classes of antidepressants are equally effective: selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and tricyclic-like compounds. More patients taking classic tricyclic antidepressants stopped their medications because of...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1101/p1503.html

Antidepressants to Treat Nonspecific Low Back Pain - Cochrane for Clinicians - American...

Jul 1, 2008 - Although antidepressants have been shown to be superior to placebo in some forms of chronic pain, they do not reduce pain or improve functional status or depression in patients with nonspecific low back pain.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0701/p51.html

Antiepileptic Drug Monotherapy for Epilepsy - Cochrane for Clinicians - American Family...

May 1, 2018 - In patients with partial-onset (focal) seizures, levetiracetam (Keppra), lamotrigine (Lamictal), and carbamazepine (Tegretol) were associated with the longest time to treatment withdrawal (i.e., the recommended patient-oriented outcome measure that balances tolerability with ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0501/p572.html

Antihistamines for the Common Cold - Cochrane for Clinicians - American Family Physician

Aug 1, 2004 - Antihistamines are of minimal to no benefit as mono-therapy for the common cold, and first-generation antihistamines may increase sedation in patients with a cold. Antihistamine-decongestant combinations reduce nasal symptoms and improve the recovery rate in older children and adults, ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/0801/p486.html

Antihypertensive Drug Therapy for Mild to Moderate Hypertension During Pregnancy - ...

Oct 1, 2019 - Compared with placebo, antihypertensive drug therapy for mild to moderate hypertension (defined by the authors as a blood pressure of 140 to 169 mm Hg systolic or 90 to 109 mm Hg diastolic) caused by chronic hypertension, gestational hypertension, or preeclampsia during pregnancy does ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1001/p403.html

Antioxidant Supplements Do Not Improve Mortality and May Cause Harm - Cochrane for ...

Nov 1, 2008 - In randomized controlled trials of primary and secondary prevention, vitamins A and E, and beta-carotene supplementation increased mortality. Vitamin C and selenium supplementation had no significant effect on mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/1101/p1079.html

Antioxidants and Minerals for Age-Related Macular Degeneration - Cochrane for ...

Sep 1, 2006 - Supplementation with a combination of vitamin C, vitamin E, beta-carotene, and zinc modestly reduces the progression of ARMD in patients with disease in one or both eyes. High-dose vitamin supplements should not be recommended for patients without ARMD because of the possible harmful ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p750.html

Antiplatelet Therapy and Anticoagulation in Patients with Hypertension - Cochrane for ...

Mar 1, 2005 - Antiplatelet agents should not be used in patients with hypertension and no previous history of heart attack or stroke. However, these agents are recommended for use in hypertensive patients who already have vascular disease. Anticoagulants should not be used for prevention of vascular ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0301/p897.html

Antiplatelet vs. Anticoagulation Therapy for Patients with Heart Failure in Sinus ...

Aug 1, 2017 - Heart failure increases the risk of thrombotic complications, but use of warfarin does not lower all-cause mortality more than aspirin in patients with heart failure with reduced ejection fraction in sinus rhythm.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0801/p160.html

Antiretroviral Therapy to Prevent Transmission in HIV-Discordant Couples - Cochrane for...

Mar 1, 2012 - Rates of HIV transmission are at least three times lower in HIV-discordant couples in which the partner with infection is receiving antiretroviral therapy, compared with HIV-discordant couples in which the partner with infection is not receiving therapy. Among HIV-discordant couples in ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0301/p445.html

Antiviral Therapy for Bell Palsy - Cochrane for Clinicians - American Family Physician

May 1, 2016 - The combination of antiviral agents and corticosteroids is more effective than corticosteroids alone for the complete recovery of patients with Bell palsy (number needed to treat [NNT] = 15) and for the resolution of motor synkinesis and excessive tear production (NNT = 12). Antivirals ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0501/p742.html

Appropriate Use of Polypharmacy for Older Patients - Cochrane for Clinicians - American...

Apr 1, 2013 - Multidisciplinary interventions that address polypharmacy decrease inappropriate prescribing and medication-related problems in patients 65 years and older, but it is not clear if they reduce hospital admissions or improve quality of life. Most interventions studied were led by ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0401/p483.html

Are Alpha-glucosidase Inhibitors Effective for Control of Type 2 Diabetes? - Cochrane ...

Feb 1, 2006 - The use of alpha-glucosidase inhibitors has a modest effect on intermediate diabetes-control endpoints such as postprandial blood glucose, postprandial insulin levels, and A1C levels. There is no evidence, however, of improvement in mortality, morbidity, or quality of life. In ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0201/p433.html

Are Anticoagulants Better than Antiplatelet Agents for Treatment of Acute Ischemic ...

Oct 1, 2003 - Aspirin has a small benefit for long-term outcome and survival. Anticoagulants increase the risk for bleeding and do not have long-term benefit.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/1001/p1307.html

Are Atypical Antipsychotics Safe in Patients with Alzheimer's Disease? - Cochrane for ...

Aug 1, 2006 - Although the atypical antipsychotic medications risperidone (Risperdal) and olanzapine (Zyprexa) are modestly efficacious in reducing aggression, routine use is not justified. Both drugs are associated with serious adverse cerebrovascular events and extrapyramidal symptoms. Use of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0801/p414.html

Are Beta Blockers Effective First-line Treatments for Hypertension? - Cochrane for ...

Nov 1, 2007 - Current evidence does not support the use of beta blockers as initial therapy for hypertension.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/1101/p1306.html

Are Cranberry Products Effective for the Prevention of Urinary Tract Infections? - ...

Dec 1, 2013 - Cranberry products are not effective and should not be recommended for the prevention of UTIs.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1201/p745.html

Are Long-acting Insulin Analogues Better Than Isophane Insulin? - Cochrane for ...

Feb 15, 2008 - Based on poor quality evidence, this review suggests that insulin glargine and insulin detemir have no advantage over isophane insulin in reducing A1C levels. In one study, isophane insulin reduced A1C levels slightly more than insulin detemir. However, patients on insulin glargine and ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0215/p447.html

Are Low-Fat Diets Better than Other Weight-Reducing Diets in Achieving Long-Term Weight...

Feb 1, 2003 - Low-fat diets are no better than low-calorie diets in achieving weight loss in overweight or obese people. In studies, the average weight loss after 18 months on either diet was less than 5 lb.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/0201/p507.html

Are Metered-Dose Inhalers with Holding Chambers Better Than Nebulizers for Treating ...

Jan 1, 2003 - In the emergency room, MDIs with holding chambers are as effective as nebulizers for delivering beta2 agonists to treat acute asthma in adults and children older than age two. There might be slightly less beta2 agonist–induced tachycardia in children when MDIs with holding chambers are ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/0101/p62.html

Are Neuraminidase Inhibitors Effective for Preventing and Treating Influenza in Healthy...

Oct 1, 2012 - Treating previously healthy patients with oseltamivir (Tamiflu) reduces the duration of influenza symptoms by approximately 21 hours, but it does not reduce the risk of hospitalization in this population.1 The data are insufficient to determine whether oseltamivir reduces the ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/1001/p624.html

Are Opioids Effective in the Treatment of Neuropathic Pain? - Cochrane for Clinicians -...

Apr 1, 2007 - Eight to 60 days of opioid therapy for the treatment of neuropathic pain effectively reduces pain scores as measured by a visual analog scale. A lack of response to opioids in the first 24 hours should not be used to predict whether longer-term opioid therapy might be beneficial. There ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0401/p999.html

Are Oral Betamimetics Effective Maintenance Therapies After Threatened Preterm Labor? -...

Mar 1, 2007 - There is no evidence to support the use of oral betamimetics for maintenance therapy after treatment for threatened preterm labor, and there is a risk of adverse effects with these drugs.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0301/p648.html

Are SSRIs Effective for Treating OCD? - Cochrane for Clinicians - American Family ...

May 1, 2008 - SSRIs are effective for the treatment of OCD. If it is assumed that 10 percent of persons with OCD will recover without treatment, then 12 persons with OCD need to be treated for one additional person to have a response within six to 13 weeks. If it is assumed that 20 percent of persons...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0501/p1252.html

Aripiprazole vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for ...

Jun 1, 2010 - Aripiprazole is less effective in treating schizophrenia than olanzapine (Zyprexa), but has fewer metabolic and sedative adverse effects. There is no difference in effectiveness between aripiprazole and risperidone (Risperdal); however, aripiprazole may be associated with less dystonia,...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0601/p1335.html

Aromatase Inhibitors Such as Letrozole (Femara) vs. Clomiphene (Clomid) for Subfertile ...

May 1, 2019 - When treated with letrozole, subfertile women with PCOS who are trying to conceive have increased chances of pregnancy (number needed to treat [NNT] = 11) and live birth (NNT = 10) compared with those treated with clomiphene.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0501/p545.html

Arthroscopic Surgery for Knee Osteoarthritis - Cochrane for Clinicians - American ...

Aug 1, 2008 - Compared with other modalities of treatment such as sham surgery, joint lavage, and joint washout, arthroscopic debridement does not improve outcomes for patients with osteoarthritis of the knee.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0801/p331.html

Aspirin Combined with Clopidogrel (Plavix) Decreases Cardiovascular Events in Patients ...

Dec 1, 2007 - A combination of aspirin and clopidogrel decreased cardiovascular events in patients at high risk of cardiovascular disease and in those with acute coronary syndrome. However, the risk of major bleeding events outweighed the benefits in all high-risk patients except those with acute ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/1201/p1643.html

Aspirin With or Without Antiemetic for Acute Migraine Headaches in Adults - Cochrane ...

Feb 1, 2014 - Aspirin, with or without an antiemetic, is an effective treatment for acute migraine headache. Adding the antiemetic metoclopramide (Reglan) significantly reduces migraine-related nausea and vomiting compared with aspirin alone.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0201/p176.html

Atypical Antipsychotics for Disruptive Behavior Disorders in Children and Adolescents -...

Jun 1, 2018 - Risperidone reduces measures of aggression and improves conduct in children with disruptive behavior disorders; however, only short-term use is recommended. Weight gain of 2 to 2.5 kg (4.4 to 5.5 lb) is common. There is insufficient evidence to evaluate the benefits of other ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0601/p715.html

Beta-Blocker Use in Patients with COPD - Cochrane for Clinicians - American Family ...

Dec 1, 2006 - In 20 studies of cardioselective beta blockers in patients with COPD, participants had no adverse pulmonary or respiratory effects. Because of their salutary cardiovascular effects, cardioselective beta blockers should not be withheld from patients with COPD.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1201/p1858.html

Beta2 Agonists for Acute Cough or a Clinical Diagnosis of Acute Bronchitis - Cochrane ...

May 1, 2017 - There is insufficient evidence to determine whether beta2 agonists can improve symptoms for children with acute cough or bronchitis with wheeze. Beta2 agonists are not likely to benefit and may cause adverse effects in adults who do not have evidence of airflow restriction (number ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0501/p551.html

Blood Pressure Targets for Patients with Hypertension and Cardiovascular Disease - ...

Sep 1, 2018 - Achieving a target BP of 135/85 mm Hg or less does not decrease the risk of total cardiovascular events vs. treating to a target of 140 to 160/90 to 100 mm Hg. Further, treating to the lower BP target does not improve total mortality, cardiovascular mortality, or serious adverse effects.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0901/p276.html

Blood Pressure Treatment Targets for Uncomplicated Hypertension - Cochrane for ...

Apr 1, 2010 - To date, there is no evidence to support treating patients with uncomplicated hypertension to blood pressure goals lower than the standard blood pressure target of less than or equal to 140 to 160/90 to 100 mm Hg. In randomized controlled trials, patients treated to lower blood pressure...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0401/p848.html

Bronchodilators for Bronchiolitis - Cochrane for Clinicians - American Family Physician

Nov 1, 2014 - Albuterol does not improve any clinical outcomes in the outpatient or inpatient setting and should not be used in the treatment of bronchiolitis in a child 24 months or younger.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/1101/p622.html

Buprenorphine Maintenance vs. Methadone Maintenance or Placebo for Opioid Use Disorder ...

Feb 1, 2015 - At dosages greater than 2 mg per day, buprenorphine maintains treatment retention better than placebo. When flexible dosing (doses adjusted based on patient symptoms) is used, the effectiveness of buprenorphine is comparable to that of methadone in suppressing opioid use.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0201/p165.html

Caffeine as an Analgesic Adjuvant for Acute Pain in Adults - Cochrane for Clinicians - ...

Jan 1, 2013 - Overall, there appears to be a small but clinically significant benefit to adding caffeine to analgesic therapy for various types of acute pain. More research is needed to determine the optimal dosing.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0101/p11.html

Calcium Supplementation for Preventing Hypertensive Disorders in Pregnancy - Cochrane ...

Oct 1, 2015 - High-dose calcium supplementation (i.e., at least 1,000 mg per day) during pregnancy reduces the risk of developing hypertension and preeclampsia. The most significant risk reduction occurs in women at risk of hypertensive disorders and those with low-calcium diets.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1001/p570.html

Can Melatonin Prevent or Treat Jet Lag? - Cochrane for Clinicians - American Family ...

Dec 1, 2002 - Daily doses of 0.5 to 5 mg of melatonin, taken at the target bedtime at the destination for two to five days after arrival, lessen the effects of jet lag.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2002/1201/p2087.html

Capsaicin for Nonallergic Rhinitis - Cochrane for Clinicians - American Family Physician

Aug 1, 2016 - Intranasal capsaicin is safe and effective for reducing symptoms of nonallergic rhinitis (number needed to treat = 4; 95% confidence interval [CI], 1 to 22). There is insufficient evidence to compare the effectiveness of capsaicin to other topical or systemic medications.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0801/p217.html

Carbamazepine for Acute and Chronic Pain - Cochrane for Clinicians - American Family ...

May 1, 2006 - Two small trials have shown carbamazepine to be beneficial in the treatment of diabetic neuropathic pain. Carbamazepine shows similar clinical effect to gabapentin (Neurontin) and phenytoin (Dilantin), but there have been no head-to-head trials directly comparing these drugs. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0501/p1549.html

Chest Physiotherapy for Pneumonia in Adults - Cochrane for Clinicians - American Family...

Dec 1, 2010 - There is little evidence to support the effectiveness of chest physiotherapy for adults with pneumonia. In two small studies by the same investigator, only osteopathic manipulation was shown to improve some outcomes (i.e., length of stay and duration of antibiotic therapy).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/1201/p1340.html

Chewing Gum for Postoperative Recovery of Gastrointestinal Function - Cochrane for ...

Dec 1, 2015 - Having patients chew gum reduces the time to first flatus and time to first bowel movement, as well as the length of hospitalization by about half a day.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1201/p974.html

Cholinesterase Inhibitors for Alzheimer's Disease - Cochrane for Clinicians - American ...

Sep 1, 2006 - Cholinesterase inhibitors produce a small benefit on several cognitive and noncognitive function scales. Although data for patients with severe dementia are sparse, there is no evidence to suggest a difference in effectiveness among patients with mild, moderate, or severe dementia. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p747.html

Citrate Salts for Preventing and Treating Calcium-Containing Kidney Stones in Adults - ...

May 1, 2017 - Citrate supplementation reduces stone size to less than 5 mm and prevents new stone formation when compared with placebo or no intervention. Citrate therapy also stabilizes existing stones and decreases the need for retreatment. These benefits come at the expense of upper ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0501/p552.html

Clozapine vs. Other Atypical Antipsychotics for Schizophrenia - Cochrane for Clinicians...

Feb 1, 2011 - Although further trials are needed, there is some evidence that clozapine is slightly more effective than risperidone (Risperdal). Fewer participants taking clozapine dropped out of studies because of lack of effectiveness compared with those taking risperidone (number needed to treat =...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/0201/p260.html

Cochrane for Clinicians - Apr 1, 2005 - American Family Physician

Apr 1, 2005 - For empiric treatment of GERD or endoscopy-negative reflux disease, a short trial of a proton pump inhibitor increases the chance of remission. Histamine H2-receptor antagonists are less expensive and work well in many patients, particularly those with less severe symptoms or ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0401/p1303a.html

Cochrane for Clinicians - Apr 1, 2005 - American Family Physician

Apr 1, 2005 - Based on three good studies of 462 patients, discontinuing epidural analgesia in the second stage of labor does not significantly change rates of instrumented delivery or other delivery outcomes, but it increases rates of inadequate pain relief.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0401/p1303.html

Cochrane for Clinicians - Apr 1, 2006 - American Family Physician

Apr 1, 2006 - The single clinical trial on this topic found that inhaled beta agonists do not reduce cough frequency or improve symptoms in children with chronic, nonspecific cough.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0401/p1191a.html

Cochrane for Clinicians - Apr 1, 2006 - American Family Physician

Apr 1, 2006 - Benzodiazepines are safe and effective for the treatment of alcohol withdrawal, particularly for the prevention of withdrawal seizures, although their superiority to anticonvulsants has not been demonstrated convincingly. There is no clear benefit of one benzodiazepine over another or ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0401/p1191.html

Cochrane for Clinicians - Apr 1, 2007 - American Family Physician

Apr 1, 2007 - Children with otitis media with effusion do not benefit from decongestants or antihistamines. Common adverse effects of these therapies are gastrointestinal upset, irritability, drowsiness, and dizziness (number needed to harm = 9).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0401/p1001.html

Cochrane for Clinicians - Apr 1, 2007 - American Family Physician

Apr 1, 2007 - Topical salicylic or lactic acid and cryotherapy are effective treatments for nongenital warts. Although cryotherapy is somewhat more effective, it is associated with more pain and blistering than salicylic or lactic acid. The spontaneous cure rate of nongenital warts is 50 to 70 ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0401/p1001a.html

Cochrane for Clinicians - Dec 1, 2004 - American Family Physician

Dec 1, 2004 - Combined evidence from two clinical trials of calcium supplementation lasting for several years revealed a reduced rate of recurrent colorectal adenoma. However, evidence is insufficient to recommend supplementation with dietary calcium for patients who have never had an adenoma.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1201/p2109.html

Cochrane for Clinicians - Dec 1, 2005 - American Family Physician

Dec 1, 2005 - In patients with moderate or severe COPD, tiotropium reduces exacerbations, hospitalizations, and symptom scores and improves health-related quality of life compared with placebo and ipratropium (Atrovent). However, more study is needed to determine tiotropium’s role in the treatment of...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1201/p2219a.html

Cochrane for Clinicians - Dec 1, 2005 - American Family Physician

Dec 1, 2005 - Three days of antibiotic therapy is as effective as longer courses for treatment of uncomplicated UTIs in women.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1201/p2219.html

Cochrane for Clinicians - Feb 1, 2006 - American Family Physician

Feb 1, 2006 - At high dosages, gabapentin is moderately effective for neuropathic pain, although adverse effects are experienced as often as benefit.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0201/p435.html

Cochrane for Clinicians - Feb 1, 2006 - American Family Physician

Feb 1, 2006 - Combined with methotrexate, subcutaneous adalimumab at a dosage of 40 mg every two weeks slows the progression of rheumatoid arthritis at one year. The combination is more effective than adalimumab monotherapy. Limited evidence suggests that adalimumab is also safe and effective when ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0201/p435a.html

Cochrane for Clinicians - Jul 1, 2006 - American Family Physician

Jul 1, 2006 - Intravenous lidocaine and oral mexiletine provide a modest reduction in neuropathic pain with no indication of serious adverse effects. However, safety data are limited because most studies were of relatively short duration and fewer than 400 patients have been studied in total for each...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0701/p79.html

Cochrane for Clinicians - Jul 1, 2006 - American Family Physician

Jul 1, 2006 - Induction of labor in patients with PROM does not increase the rates of cesarean delivery or operative vaginal delivery. Among patients who are induced there is a slightly lower incidence of chorioamnionitis (relative risk [RR] 0.74; 95% confidence interval [CI], 0.56 to 0.97) and a ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0701/p79a.html

Cochrane for Clinicians - Jun 1, 2005 - American Family Physician

Jun 1, 2005 - Many patients request delayed umbilical cord clamping in their birth plans. Delayed cord clamping allows continued perfusion while the baby transitions to newborn circulation. However, when an infant is high risk, physicians frequently clamp and cut the cord early to allow the neonatal ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0601/p2091a.html

Cochrane for Clinicians - Jun 1, 2005 - American Family Physician

Jun 1, 2005 - Thickened feeds and metoclopramide reduce symptoms of GER in normally developing infants. However, elevating the head of the crib appears to have no effect.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0601/p2091.html

Cochrane for Clinicians - Jun 1, 2006 - American Family Physician

Jun 1, 2006 - An antidepressant such as imipramine (Tofranil) or sertraline (Zoloft), possibly with the addition of an antipsychotic, is the preferred initial pharmacologic treatment for psychotic depression.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0601/p1935.html

Cochrane for Clinicians - Jun 1, 2006 - American Family Physician

Jun 1, 2006 - For adult patients who are taking a minimum maintenance dosage of inhaled corticosteroid for asthma, adding a long-acting beta2 agonist permits reduction of the dosage of inhaled corticosteroid by 253 mcg beclomethasone equivalent per day without worsening the patient's symptoms. In ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0601/p1935a.html

Cochrane for Clinicians - Mar 1, 2005 - American Family Physician

Mar 1, 2005 - NPH insulin and metformin taken at bedtime appears to be the most favorable combination studied, but this conclusion is based on poor-quality, inconsistent studies that measure disease-oriented outcomes. There are no data on the effect of these drug combinations on patient-oriented ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0301/p899.html

Cochrane for Clinicians - Mar 1, 2005 - American Family Physician

Mar 1, 2005 - Treatment with betamimetics decreases the number of women with preterm labor who give birth within 48 hours, but it does not decrease the number of births within seven days. Limited evidence suggests that treatment with beta-mimetics does not decrease perinatal death or morbidity.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/0301/p899a.html

Cochrane for Clinicians - Oct 1, 2005 - American Family Physician

Oct 1, 2005 - Although no difference in effectiveness has been demonstrated in existing trials, too few patients have been studied to detect small but clinically important differences in pregnancy rates. Low-dose estrogen pills have higher rates of discontinuation and bleeding disturbances.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1001/p1224a.html

Cochrane for Clinicians - Oct 1, 2005 - American Family Physician

Oct 1, 2005 - There is limited, weak evidence that a low glycemic index diet improves risk factors for CHD, but there are no randomized controlled trials (RCTs) showing a reduction in morbidity or mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2005/1001/p1224.html

Cognitive Interventions for Improving Cognitive Function - Cochrane for Clinicians - ...

Nov 1, 2011 - Compared with no treatment, cognitive interventions improved cognitive performance in healthy older adults and older adults with mild cognitive impairments. However, there is inadequate evidence to determine which aspects of these interventions are effective.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1101/p992.html

Colchicine for Acute Gout - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p759.html

Collaborative Care for Depression and Anxiety - Cochrane for Clinicians - American ...

Apr 1, 2014 - The collaborative care model is effective for treating adults with depression and/or anxiety using a multiprofessional approach to patient care, a structured management plan, scheduled patient follow-ups, and enhanced interprofessional communication.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0401/p524.html

Combined Hormonal Contraceptives for Heavy Menstrual Bleeding - Cochrane for Clinicians...

Dec 1, 2019 - Combined oral contraceptives decrease the number of women reporting menorrhagia over six months compared with placebo (absolute risk reduction = 36.7%; number needed to treat = 2.7).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/1201/p677.html

Complementary and Integrative Treatments for Pain Management in Labor - Cochrane for ...

Feb 1, 2019 - There is evidence that all of the studied interventions have some benefit in labor, but the evidence is of low to very low quality. Massage, thermal interventions (warm and cold packs), relaxation techniques, yoga, and music reduce pain during latent labor, but not during active labor.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0201/p154.html

Contraceptive Education for Women After Childbirth - Cochrane for Clinicians - American...

Jun 1, 2013 - Postpartum education may increase contraceptive use and reduce unplanned repeat pregnancies, although the evidence is mixed. The optimal timing and content of educational programs are not known.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0601/p761.html

Contraceptive Patch and Vaginal Ring vs. Combined Oral Contraceptives - Cochrane for ...

Aug 1, 2009 - Based on moderate quality evidence, contraceptive effectiveness of the vaginal ring or patch is similar to COC. Compliance is better with the patch, but its use is discontinued more often than COCs or the ring because of adverse effects. Vaginal ring and COC users have similar rates of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0801/p232.html

Controlled-Release Oxycodone for Neuropathic Pain and Fibromyalgia in Adults - Cochrane...

Mar 1, 2015 - Oxycodone CR has limited effectiveness for the treatment of diabetic neuropathy or postherpetic neuralgia. Evidence is lacking regarding treatment benefit for other neuropathic pain syndromes or fibromyalgia. Adverse effects of oxycodone CR therapy are common.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0301/p286.html

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