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A Family Physicians' Guide to Monitoring Methotrexate - American Family Physician

Oct 1, 2000 - Methotrexate has a long history of use in the treatment of various immunologic diseases, including rheumatoid arthritis and psoriasis. Although the drug is usually prescribed by a subspecialist, a family physician may assume responsibility for monitoring methotrexate therapy. Major ...

American Family Physician : Article

https://www.aafp.org/afp/2000/1001/p1607.html

Acetaminophen (Paracetamol) Minimally Effective for Back Pain and Osteoarthritis - ...

Oct 1, 2015 - Although acetaminophen was hoped to be a safer alternative to nonsteroidal anti-inflammatory drugs and opioids for the treatment of common musculoskeletal problems, on average it provides only minimal pain relief and improvement in function for patients with low back pain or ...

American Family Physician : POEMs

https://www.aafp.org/afp/2015/1001/p642.html

ACR Issues Recommendations on Therapies for Osteoarthritis of the Hand, Hip, and Knee -...

Apr 1, 2013 - The American College of Rheumatology (ACR) has released updated recommendations for the treatment of osteoarthritis of the hip and knee, and has developed new recommendations for the treatment of osteoarthritis of the hand. These recommendations are categorized as strong or conditional.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2013/0401/p515.html

ACR Publishes Guidelines for Pharmacologic and Nonpharmacologic Treatment of Gout - ...

Sep 15, 2013 - The American College of Rheumatology (ACR) has developed recommendations for the management of gout. The recommendations call for a systematic nonpharmacologic and pharmacologic management approach that is intended to be applicable to all patients with gout.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2013/0915/p408.html

Adalimumab (Humira) for the Treatment of Rheumatoid Arthritis - STEPS - American Family...

Dec 15, 2008 - Adalimumab used alone offers little benefit over the traditional first-line agent, methotrexate. However, it increases remission rates when combined with methotrexate in early aggressive rheumatoid arthritis and when combined with traditional DMARDs in those who have not derived benefit...

American Family Physician : STEPS

https://www.aafp.org/afp/2008/1215/p1406.html

Advances in the Treatment of Early Rheumatoid Arthritis - Editorials - American Family ...

Sep 15, 2005 - Advertisement << Previous article Next article >> Sep 15, 2005 Issue Editorials Advances in the Treatment of Early Rheumatoid Arthritis EDWARD M. J. VITAL, M.B.CH.B., The General Infirmary at Leeds, Leeds, United Kingdom PAUL EMERY, M.A., M.D., University of Leeds Faculty of Medicine...

American Family Physician : Editorials

https://www.aafp.org/afp/2005/0915/p1002.html

AGA Reviews the Use of Corticosteroids Immunomodulators, and Infliximab in IBD - ...

Feb 1, 2007 - The American Gastroenterological Association Institute (AGA) has issued a clinical position statement on corticosteroids, immunomodulators, and infliximab (Remicade) use in managing inflammatory bowel disease (IBD).

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2007/0201/p410.html

All Analgesics Are Better Than Placebo in Patients with Knee or Hip DJD - POEMs - ...

Oct 15, 2016 - In patients with hip or knee DJD, all analgesics are more effective than placebo in relieving pain and improving function. Although paracetamol (acetaminophen) is the least effective of all the drugs studied, it still may be the first treatment for these patients because of its safety ...

American Family Physician : POEMs

https://www.aafp.org/afp/2016/1015/p664.html

Allopurinol Hypersensitivity Assay HLA-B*58:01 Genotyping - Diagnostic Tests: What ...

Nov 1, 2019 - The allopurinol hypersensitivity assay, or HLA-B*58:01 test, is a blood test to detect the presence of a human leukocyte antigen B (HLA-B) genetic variant that increases the risk of life-threatening, severe cutaneous adverse reactions in patients taking allopurinol.

American Family Physician : Diagnostic Tests: What Physicians Need to Know

https://www.aafp.org/afp/2019/1101/p530.html

Analgesics for Osteoarthritis - Implementing AHRQ Effective Health Care Reviews - ...

Mar 1, 2013 - What are the comparative effectiveness, benefits, and adverse effects of oral and topical analgesics for osteoarthritis?

American Family Physician : Implementing AHRQ Effective Health Care Reviews

https://www.aafp.org/afp/2013/0301/p354.html

Antipsychotics for Fibromyalgia in Adults - Medicine by the Numbers - American Family ...

Aug 1, 2017 - Quetiapine may be considered for a limited period (less than 12 weeks) to improve pain, sleep, and depression in fibromyalgia, while considering the potential for weight gain.

American Family Physician : Medicine by the Numbers

https://www.aafp.org/afp/2017/0801/od1.html

Are Selective COX-2 Inhibitors as Effective as NSAIDs in Patients with Rheumatoid ...

Feb 1, 2004 - The efficacy of COX-2 inhibitors is similar to that of nonselective NSAIDs in reducing the symptoms of rheumatoid arthritis.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2004/0201/p595.html

Chronic Musculoskeletal Pain in Children: Part II. Rheumatic Causes - American Family ...

Jul 15, 2006 - Primary care physicians should have a working knowledge of rheumatic diseases of childhood that manifest primarily as musculoskeletal pain. Children with juvenile rheumatoid arthritis can present with painless joint inflammation and may have normal results on rheumatologic tests. ...

American Family Physician : Article

https://www.aafp.org/afp/2006/0715/p293.html

Cochrane for Clinicians - Feb 1, 2006 - American Family Physician

Feb 1, 2006 - At high dosages, gabapentin is moderately effective for neuropathic pain, although adverse effects are experienced as often as benefit.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0201/p435.html

Cochrane for Clinicians - Feb 1, 2006 - American Family Physician

Feb 1, 2006 - Combined with methotrexate, subcutaneous adalimumab at a dosage of 40 mg every two weeks slows the progression of rheumatoid arthritis at one year. The combination is more effective than adalimumab monotherapy. Limited evidence suggests that adalimumab is also safe and effective when ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0201/p435a.html

Colchicine for Acute Gout - Cochrane for Clinicians - American Family Physician

Jun 1, 2015 - Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0601/p759.html

Controlled-Release Oxycodone for Neuropathic Pain and Fibromyalgia in Adults - Cochrane...

Mar 1, 2015 - Oxycodone CR has limited effectiveness for the treatment of diabetic neuropathy or postherpetic neuralgia. Evidence is lacking regarding treatment benefit for other neuropathic pain syndromes or fibromyalgia. Adverse effects of oxycodone CR therapy are common.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0301/p286.html

Corticosteroid Injections for Common Musculoskeletal Conditions - American Family ...

Oct 15, 2015 - Family physicians considering corticosteroid injections as part of a comprehensive treatment plan for musculoskeletal diagnoses will find few high-quality studies to assist with evidence-based decision making. Most studies of corticosteroid injections for the treatment of ...

American Family Physician : Article

https://www.aafp.org/afp/2015/1015/p694.html

Corticosteroid Injections Ineffective for Knee Osteoarthritis - POEMs - American Family...

Sep 15, 2017 - This well-done study found that regular three-month intra-articular injections of triamcinolone for two years resulted in no significant difference in pain and function assessments compared with saline. However, a significant increase in cartilage loss and damage did occur in patients ...

American Family Physician : POEMs

https://www.aafp.org/afp/2017/0915/p406.html

Denosumab (Prolia) for Treatment of Postmenopausal Osteoporosis - STEPS - American ...

Feb 15, 2012 - Prolia is an expensive method of preventing osteoporotic hip fractures, and is associated with significant adverse effects. Safer, less expensive options exist for preventing fracture in high-risk women.

American Family Physician : STEPS

https://www.aafp.org/afp/2012/0215/p334.html

Dietary Supplements for Osteoarthritis - American Family Physician

Jan 15, 2008 - A large number of dietary supplements are promoted to patients with osteoarthritis and as many as one third of those patients have used a supplement to treat their condition. Glucosamine-containing supplements are among the most commonly used products for osteoarthritis. Although the ...

American Family Physician : Article

https://www.aafp.org/afp/2008/0115/p177.html

Duration of Bisphosphonate Therapy - FPIN's Help Desk Answers - American Family Physician

Apr 1, 2018 - Oral bisphosphonates significantly reduce clinical fracture risk at four years in women with postmenopausal osteoporosis (T-score less than −2.5). Treatment beyond five years is associated with further reductions in fractures in women with persistent femoral neck T-scores less than −2.5.

American Family Physician : FPIN's Help Desk Answers

https://www.aafp.org/afp/2018/0401/od1.html

Effectiveness and Safety of Celecoxib for the Treatment of Rheumatoid Arthritis - ...

May 1, 2018 - Compared with placebo, celecoxib improves pain (number needed to treat [NNT] = 4) and clinical symptoms (NNT = 7), but it has no effect on physical function in patients with RA.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0501/p573.html

Exercise for Osteoarthritis of the Knee - Cochrane for Clinicians - American Family ...

Nov 1, 2015 - Land-based exercise programs reduce knee pain and improve quality of life and physical function following treatment in patients with knee osteoarthritis.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1101/p774.html

Febuxostat (Uloric) for Hyperuricemia and Gout - STEPS - American Family Physician

May 15, 2010 - Febuxostat more effectively lowers serum uric acid to goal levels than does allopurinol; however, this benefit is offset by a slightly higher incidence of adverse effects and treatment discontinuation. Until superiority for patient-oriented outcomes is shown in comparative trials with ...

American Family Physician : STEPS

https://www.aafp.org/afp/2010/0515/p1287.html

Febuxostat Increases All-Cause and Cardiovascular Mortality Compared with Allopurinol -...

Sep 15, 2018 - For patients with gout who require treatment to lower their uric acid level, allopurinol is a safer option than febuxostat.

American Family Physician : POEMs

https://www.aafp.org/afp/2018/0915/p385.html

Hip Fracture: Diagnosis, Treatment, and Secondary Prevention - American Family Physician

Jun 15, 2014 - Hip fractures cause significant morbidity and are associated with increased mortality. Women experience 80% of hip fractures, and the average age of persons who have a hip fracture is 80 years. Most hip fractures are associated with a fall, although other risk factors include decreased ...

American Family Physician : Article

https://www.aafp.org/afp/2014/0615/p945.html

Human Parathyroid Hormone for Treating Osteoporosis - FPIN's Clinical Inquiries - ...

Feb 1, 2012 - Human parathyroid hormone should be used in patients with severe osteoporosis to decrease the rate of vertebral and nonvertebral fractures.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2012/0201/od1.html

Intra-articular Corticosteroid Injections for Osteoarthritis of the Knee - FPIN's ...

Jul 15, 2014 - Intra-articular corticosteroid injections can be used to reduce pain by about 20% in the short term (one to three weeks) in patients with osteoarthritis of the knee.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2014/0715/p115.html

Is Leflunomide as Safe and Effective in the Treatment of Rheumatoid Arthritis as Other ...

Sep 1, 2003 - Compared with placebo, leflunomide improves clinical outcomes and delays radiologic progression of rheumatoid arthritis. After two years of treatment, leflunomide is as safe as sulfasalazine and more effective. Leflunomide's efficacy and adverse events are similar to those of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/0901/p849.html

Lesinurad (Zurampic) for Gout - STEPS - American Family Physician

Mar 15, 2018 - Lesinurad taken in addition to a xanthine oxidase inhibitor reduces serum uric acid levels. However, it does not reduce the likelihood of experiencing a gout flare-up or completely resolving tophi.

American Family Physician : STEPS

https://www.aafp.org/afp/2018/0315/p374.html

Long-Term Use of Bisphosphonates Increases the Risk of Fractures in Older Women - POEMs...

Jan 1, 2018 - In this cohort study, older women at a high risk of fractures who used oral bisphosphonates for 10 to 13 years had a higher risk of fractures than women who used bisphosphonates for only two years.

American Family Physician : POEMs

https://www.aafp.org/afp/2018/0101/p53a.html

Management of Giant Cell Arteritis and Polymyalgia Rheumatica - American Family Physician

Apr 1, 2000 - Giant cell arteritis and polymyalgia rheumatica are closely related disorders that affect persons more than 50 years of age and cause substantial morbidity. Patients with giant cell arteritis typically have a localized headache, nonspecific systemic symptoms, temporal artery tenderness ...

American Family Physician : Article

https://www.aafp.org/afp/2000/0401/p2061.html

Methotrexate Therapy for Rheumatoid Arthritis - Cochrane for Clinicians - American ...

Jan 1, 2015 - Methotrexate monotherapy demonstrated statistically significant and clinically relevant improvement of symptoms and physical function compared with placebo at 12 to 52 weeks. Multiple adverse effects were reported with methotrexate use, and patients were twice as likely to discontinue ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/0101/p26.html

Milnacipran (Savella) for Fibromyalgia - STEPS - American Family Physician

Oct 15, 2010 - Milnacipran can decrease the overall pain scores and improve symptoms of fibromyalgia. Safety in patients with severe comorbid medical and psychiatric conditions is unknown because these groups of patients were excluded from the study.

American Family Physician : STEPS

https://www.aafp.org/afp/2010/1015/p901.html

Omega-3 Fatty Acids - American Family Physician

Jul 1, 2004 - Omega-3 fatty acids have been shown to significantly reduce the risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease. Fatty fish, such as salmon and tuna, and fish oil are rich sources of the omega-3 fatty acids ...

American Family Physician : Article

https://www.aafp.org/afp/2004/0701/p133.html

Pregabalin (Lyrica) for Acute Fibromyalgia Pain - Medicine by the Numbers - American ...

May 1, 2018 - Pregabalin (Lyrica) provides good pain relief to some patients with acute fibromyalgia pain but does not work for most persons. Learn more.

American Family Physician : Medicine by the Numbers

https://www.aafp.org/afp/2018/0501/od1.html

Pregabalin for Fibromyalgia Pain in Adults - Cochrane for Clinicians - American Family ...

Sep 1, 2017 - There is high-quality evidence that pregabalin in daily dosages of 300 mg, 450 mg, and 600 mg reduces pain associated with fibromyalgia. The most effective dosage seems to be 450 mg daily; this dosage is more effective than placebo at reducing pain by at least 50% (number needed to ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0901/p291.html

Primary Raynaud Phenomenon - Clinical Evidence Handbook - American Family Physician

Sep 15, 2014 - What are the effects of drug treatments for primary Raynaud phenomenon?

American Family Physician : Clinical Evidence Handbook

https://www.aafp.org/afp/2014/0915/p403.html

Rheumatoid Arthritis - Clinical Evidence Handbook - American Family Physician

Nov 1, 2003 - What are the effects of treatments?

American Family Physician : Clinical Evidence Handbook

https://www.aafp.org/afp/2003/1101/p1821.html

Risk of Gout with the Use of Thiazide Diuretics - FPIN's Clinical Inquiries - American ...

Oct 1, 2015 - Thiazide diuretics may be used in most patients with hypertension who have only minimally increased risk of gout.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2015/1001/p622.html

Risks of Bisphosphonate Use - FPIN's Clinical Inquiries - American Family Physician

Nov 15, 2013 - Bisphosphonates are associated with a small risk of atypical femoral shaft fractures, which increases with duration of use. Bisphosphonates are associated with a small risk of osteonecrosis of the jaw, which is more common in patients who are older, female, or have poor dental hygiene ...

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2013/1115/p697.html

Selective Serotonin Reuptake Inhibitors for Fibromyalgia - Cochrane for Clinicians - ...

Oct 1, 2016 - SSRIs may have a small to moderate effect on pain (number needed to treat [NNT] = 10), global improvement (NNT = 7), and depression (NNT = 13) in patients with fibromyalgia, but the quality of evidence is very low because of bias and small studies. SSRIs do not reduce fatigue related to...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1001/p548.html

Topical NSAIDs for Chronic Musculoskeletal Pain in Adults - Cochrane for Clinicians - ...

Nov 1, 2017 - Topical diclofenac and ketoprofen are slightly more effective than placebo for relieving chronic pain associated with osteoarthritis in adults. Evidence is lacking to determine the effectiveness of topical NSAIDs compared with oral NSAIDs.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/1101/p573.html

Treating Fibromyalgia - American Family Physician

Oct 1, 2000 - Fibromyalgia is an extremely common chronic condition that can be challenging to manage. Although the etiology remains unclear, characteristic alterations in the pattern of sleep and changes in neuroendocrine transmitters such as serotonin, substance P, growth hormone and cortisol ...

American Family Physician : Article

https://www.aafp.org/afp/2000/1001/p1575.html

Treating Fibromyalgia: Science vs. Art - Editorials - American Family Physician

Oct 1, 2000 - Advertisement << Previous article Next article >> Oct 1, 2000 Issue Editorials Treating Fibromyalgia: Science vs. Art DANIEL J. CLAUW, M.D., Georgetown University Medical Center, Washington, D.C. Am Fam Physician. 2000 Oct 1;62(7):1492-1494. Related Article In this issue of...

American Family Physician : Editorials

https://www.aafp.org/afp/2000/1001/p1492.html

Treatment of Knee Osteoarthritis - Implementing AHRQ Effective Health Care Reviews - ...

Nov 1, 2018 - What are the clinical effectiveness and harms of cell-based therapies, oral glucosamine and/or chondroitin, physical treatment interventions, weight loss, and home-based and self-management therapies for knee osteoarthritis?

American Family Physician : Implementing AHRQ Effective Health Care Reviews

https://www.aafp.org/afp/2018/1101/p603.html

Treatment of Knee Osteoarthritis: A Clinical Practice Guideline from the AAOS - ...

Jun 1, 2014 - This clinical guideline from the American Academy of Orthopaedic Surgeons (AAOS) updates the one previously published in 2008 and addresses treatment of symptomatic knee osteoarthritis in adults 19 years and older.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2014/0601/p918.html

Treatment of Systemic Lupus Erythematosus: An Update - American Family Physician

Jun 1, 1998 - Systemic lupus erythematosus predominantly affects women and is more common in blacks. Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most ...

American Family Physician : Article

https://www.aafp.org/afp/1998/0601/p2753.html

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