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Vitamin B12 Deficiency: Recognition and Management - American Family Physician

Sep 15, 2017 - Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B12 deficiency is not recommended. Screening may be warranted in patients with one or more risk factors, such...

American Family Physician : Article

https://www.aafp.org/afp/2017/0915/p384.html

Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis - American Family ...

Dec 1, 2016 - Lymphadenopathy is benign and self-limited in most patients. Etiologies include malignancy, infection, and autoimmune disorders, as well as medications and iatrogenic causes. The history and physical examination alone usually identify the cause of lymphadenopathy. When the cause is ...

American Family Physician : Article

https://www.aafp.org/afp/2016/1201/p896.html

Evaluation of Patients with Leukocytosis - American Family Physician

Dec 1, 2015 - An elevated white blood cell count has many potential etiologies, including malignant and nonmalignant causes. It is important to use age- and pregnancy-specific normal ranges for the white blood cell count. A repeat complete blood count with peripheral smear may provide helpful ...

American Family Physician : Article

https://www.aafp.org/afp/2015/1201/p1004.html

Hemolytic Anemia: Evaluation and Differential Diagnosis - American Family Physician

Sep 15, 2018 - Hemolytic anemia is defined by the premature destruction of red blood cells, and can be chronic or life-threatening. It should be part of the differential diagnosis for any normocytic or macrocytic anemia. Hemolysis may occur intravascularly, extravascularly in the reticuloendothelial ...

American Family Physician : Article

https://www.aafp.org/afp/2018/0915/p354.html

Iron Deficiency and Other Types of Anemia in Infants and Children - American Family ...

Feb 15, 2016 - Anemia, defined as a hemoglobin level two standard deviations below the mean for age, is prevalent in infants and children worldwide. The evaluation of a child with anemia should begin with a thorough history and risk assessment. Characterizing the anemia as microcytic, normocytic, or ...

American Family Physician : Article

https://www.aafp.org/afp/2016/0215/p270.html

Iron Deficiency Anemia: Evaluation and Management - American Family Physician

Jan 15, 2013 - Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal. Women should be...

American Family Physician : Article

https://www.aafp.org/afp/2013/0115/p98.html

Anemia in Older Adults - American Family Physician

Oct 1, 2018 - Anemia is associated with increased morbidity and mortality in older adults. Diagnostic cutoff values for defining anemia vary with age, sex, and possibly race. Anemia is often asymptomatic and discovered incidentally on laboratory testing. Patients may present with symptoms related to ...

American Family Physician : Article

https://www.aafp.org/afp/2018/1001/p437.html

Clinical Evaluation of Bleeding and Bruising in Primary Care - American Family Physician

Feb 15, 2016 - Bleeding and bruising are common symptoms in the primary care setting. The patient history can help determine whether the bruising or bleeding is abnormal. The International Society on Thrombosis and Hemostasis has developed a bleeding assessment tool that can be used to indicate ...

American Family Physician : Article

https://www.aafp.org/afp/2016/0215/p279.html

Management of Sickle Cell Disease: Recommendations from the 2014 Expert Panel Report - ...

Dec 15, 2015 - Family physicians are the primary and sometimes only health care resource for families affected by sickle cell disease. Recently published guidelines provide important recommendations for health maintenance, acute care, and monitoring of disease-modifying therapy in persons with this ...

American Family Physician : Article

https://www.aafp.org/afp/2015/1215/p1069.html

Thrombocytopenia - American Family Physician

Mar 15, 2012 - Thrombocytopenia is defined as a platelet count of less than 150 × 103 per µL. It is often discovered incidentally when obtaining a complete blood count during an office visit. The etiology usually is not obvious, and additional investigation is required. Patients with platelet counts ...

American Family Physician : Article

https://www.aafp.org/afp/2012/0315/p612.html

Evaluation of Anemia in Children - American Family Physician

Jun 15, 2010 - Anemia is defined as a hemoglobin level of less than the 5th percentile for age. Causes vary by age. Most children with anemia are asymptomatic, and the condition is detected on screening laboratory evaluation. Screening is recommended only for high-risk children. Anemia is classified ...

American Family Physician : Article

https://www.aafp.org/afp/2010/0615/p1462.html

Alpha and Beta Thalassemia - American Family Physician

Aug 15, 2009 - The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of...

American Family Physician : Article

https://www.aafp.org/afp/2009/0815/p339.html

Leukemia: An Overview for Primary Care - American Family Physician

May 1, 2014 - Leukemia is a clonal proliferation of hematopoietic stem cells in the bone marrow. The four broad subtypes most likely to be encountered by primary care physicians are acute lymphoblastic, acute myelogenous, chronic lymphocytic, and chronic myelogenous. Acute lymphoblastic leukemia ...

American Family Physician : Article

https://www.aafp.org/afp/2014/0501/p731.html

Hereditary Hemochromatosis - American Family Physician

Feb 1, 2013 - Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body’s regulation of iron. It is the most common genetic disease in whites. Men have a 24-fold increased rate of iron-overload disease compared with women. Persons who are homozygous for the HFE gene ...

American Family Physician : Article

https://www.aafp.org/afp/2013/0201/p183.html

Evaluation of Microcytosis - American Family Physician

Nov 1, 2010 - Microcytosis is typically an incidental finding in asymptomatic patients who received a complete blood count for other reasons. The condition is defined as a mean corpuscular volume of less than 80 µm3 (80 fL) in adults. The most common causes of microcytosis are iron deficiency anemia ...

American Family Physician : Article

https://www.aafp.org/afp/2010/1101/p1117.html

Evaluation of Macrocytosis - American Family Physician

Feb 1, 2009 - Macrocytosis, generally defined as a mean corpuscular volume greater than 100 fL, is frequently encountered when a complete blood count is performed. The most common etiologies are alcoholism, vitamin B12 and folate deficiencies, and medications. History and physical examination, ...

American Family Physician : Article

https://www.aafp.org/afp/2009/0201/p203.html

Diagnosis and Management of Von Willebrand Disease: Guidelines for Primary Care - ...

Dec 1, 2009 - Von Willebrand disease is an inherited condition characterized by deficiency of von Willebrand factor, which is essential in hemostasis. The National Heart, Lung, and Blood Institute has released new evidence-based guidelines for the diagnosis and management of the disease. There are ...

American Family Physician : Article

https://www.aafp.org/afp/2009/1201/p1261.html

Understanding and Interpreting the Serum Protein Electrophoresis - American Family ...

Jan 1, 2005 - Serum protein electrophoresis is used to identify patients with multiple myeloma and other serum protein disorders. Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. Plasma protein levels ...

American Family Physician : Article

https://www.aafp.org/afp/2005/0101/p105.html

Anemia in Older Persons - American Family Physician

Sep 1, 2010 - Anemia in older persons is commonly overlooked despite mounting evidence that low hemoglobin levels are a significant marker of physiologic decline. Using the World Health Organization definition of anemia (hemoglobin level less than 13 g per dL [130 g per L] in men and less than 12 g ...

American Family Physician : Article

https://www.aafp.org/afp/2010/0901/p480.html

Iron Deficiency Anemia - American Family Physician

Mar 1, 2007 - The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent in non-Hispanic white women, and nearly 20 percent in black and Mexican-American women. Nine percent of patients older than 65 years with iron deficiency anemia have a gastrointestinal cancer when ...

American Family Physician : Article

https://www.aafp.org/afp/2007/0301/p671.html

Lymphadenopathy: Differential Diagnosis and Evaluation - American Family Physician

Oct 15, 1998 - Although the finding of lymphadenopathy sometimes raises fears about serious illness, it is, in patients seen in primary care settings, usually a result of benign infectious causes. Most patients can be diagnosed on the basis of a careful history and physical examination. Localized ...

American Family Physician : Article

https://www.aafp.org/afp/1998/1015/p1313.html

Vitamin B12 Deficiency - American Family Physician

Mar 1, 2003 - Vitamin B12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders. The role of B12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored. Diagnosis of vitamin B12 ...

American Family Physician : Article

https://www.aafp.org/afp/2003/0301/p979.html

Hemolytic Anemia - American Family Physician

Jun 1, 2004 - Hemolysis presents as acute or chronic anemia, reticulocytosis, or jaundice. The diagnosis is established by reticulocytosis, increased unconjugated bilirubin and lactate dehydrogenase, decreased haptoglobin, and peripheral blood smear findings. Premature destruction of erythrocytes ...

American Family Physician : Article

https://www.aafp.org/afp/2004/0601/p2599.html

Anemia in the Elderly - American Family Physician

Oct 1, 2000 - Anemia should not be accepted as an inevitable consequence of aging. A cause is found in approximately 80 percent of elderly patients. The most common causes of anemia in the elderly are chronic disease and iron deficiency. Vitamin B12 deficiency, folate deficiency, gastrointestinal ...

American Family Physician : Article

https://www.aafp.org/afp/2000/1001/p1565.html

Polycythemia Vera - American Family Physician

May 1, 2004 - Polycythemia vera is a chronic myeloproliferative disorder characterized by increased red blood cell mass. The resultant hyperviscosity of the blood predisposes such patients to thrombosis. Polycythemia vera should be suspected in patients with elevated hemoglobin or hematocrit levels, ...

American Family Physician : Article

https://www.aafp.org/afp/2004/0501/p2139.html

Normocytic Anemia - American Family Physician

Nov 15, 2000 - Anemia is a common problem that is often discovered on routine laboratory tests. Its prevalence increases with age, reaching 44 percent in men older than 85 years. Normocytic anemia is the most frequently encountered type of anemia. Anemia of chronic disease, the most common normocytic ...

American Family Physician : Article

https://www.aafp.org/afp/2000/1115/p2255.html

Warfarin Therapy: Evolving Strategies in Anticoagulation - American Family Physician

Feb 1, 1999 - Warfarin is the oral anticoagulant most frequently used to control and prevent thromboembolic disorders. Prescribing the dose that both avoids hemorrhagic complications and achieves sufficient suppression of thrombosis requires a thorough understanding of the drug's unique pharmacology....

American Family Physician : Article

https://www.aafp.org/afp/1999/0201/p635.html

Recognition and Management of Hereditary Hemochromatosis - American Family Physician

Mar 1, 2002 - Hereditary hemochromatosis is the most common inherited single-gene disorder in people of northern European descent. It is characterized by increased intestinal absorption of iron, with deposition of the iron in multiple organs. Previously, the classic description was combined diabetes ...

American Family Physician : Article

https://www.aafp.org/afp/2002/0301/p853.html

Evaluating the Child with Purpura - American Family Physician

Aug 1, 2001 - Purpura is the result of hemorrhage into the skin or mucosal membrane. It may represent a relatively benign condition or herald the presence of a serious underlying disorder. Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation factor deficiency or vascular ...

American Family Physician : Article

https://www.aafp.org/afp/2001/0801/p419.html

Low-Molecular Weight Heparin in Preventing and Treating DVT - American Family Physician

Mar 15, 1999 - Low-molecular-weight heparin is a relatively recent addition to the list of therapies for prophylaxis and treatment of deep venous thrombosis (DVT). As a prophylactic, low-molecular-weight heparin is as effective as standard heparin or warfarin and does not require monitoring of the ...

American Family Physician : Article

https://www.aafp.org/afp/1999/0315/p1607.html

Low-Molecular-Weight Heparin in Treatment of DVT - American Family Physician

Feb 15, 1999 - Patients with a diagnosis of acute deep venous thrombosis have traditionally been hospitalized and treated with unfractionated heparin followed by oral anticoagulation therapy. Several clinical trials have shown that low-molecular-weight heparin is at least as safe and effective as ...

American Family Physician : Article

https://www.aafp.org/afp/1999/0215/p945.html

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