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Hyperlipidemia - American Family Physician

Dec 15, 2019 - This collection features AFP content on hyperlipidemia and related issues, including dyslipidemia, hypercholesterolemia, hypertriglyceridemia, kidney disease, lipid disorders, metabolic syndrome, statins, and triglyceride levels. This collection features AFP content on hyperlipidemia ...

American Family Physician : AFP By Topic

https://www.aafp.org/afp/topicModules/viewTopicModule.htm?topicModuleId=13

Overuse of Statins in Older Adults - Lown Right Care: Reducing Overuse and Underuse - ...

Dec 15, 2019 - A collaboration between AFP and the Lown Institute promotes a vision of delivering heath care that is based on the evidence, balanced in its approach, and focused on the patient.

American Family Physician : Lown Right Care: Reducing Overuse and Underuse

https://www.aafp.org/afp/2019/1215/p742.html

Cholesterol Management: ACC/AHA Updates Guideline - Practice Guidelines - American ...

May 1, 2019 - The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol guideline.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2019/0501/p589.html

Statins Ineffective for Primary Prevention of Cardiovascular Disease in Patients 75 ...

Apr 1, 2019 - In this retrospective study, statin treatment in patients 75 years or older without preexisting CVD did not change the likelihood of developing CVD or reduce any-cause mortality. However, patients 75 to 84 years of age with diabetes mellitus benefitted from treatment. These results ...

American Family Physician : POEMs

https://www.aafp.org/afp/2019/0401/p461.html

Statins Effective for LDL 190 mg per dL or Higher, Regardless of Risk Level - POEMs - ...

Jul 1, 2018 - These results confirm that the use of statins for men with an LDL cholesterol level of at least 190 mg per dL, regardless of calculated risk, is associated with a clinically and statistically significant reduction in cardiovascular events and probably cardiovascular and all-cause ...

American Family Physician : POEMs

https://www.aafp.org/afp/2018/0701/p54a.html

Omega-3 Fatty Acids and Cardiovascular Disease - Implementing AHRQ Effective Health ...

May 1, 2018 - What is the effect of omega-3 fatty acid supplementation on cardiovascular outcomes?

American Family Physician : Implementing AHRQ Effective Health Care Reviews

https://www.aafp.org/afp/2018/0501/p562.html

Use of Niacin for Primary or Secondary Prevention of Cardiovascular or Cerebrovascular ...

Apr 1, 2018 - Prescription niacin (nicotinic acid, vitamin B3) does not reduce myocardial infarctions, strokes, or overall mortality when used for primary or secondary prevention.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0401/p436.html

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults - Putting ...

Dec 15, 2017 - L.D., a 66-year-old generally healthy white man, presents for his annual physical. He has no history of cardiovascular disease (CVD); he has had consistent systolic blood pressure measurements of 140 mm Hg; he is not taking any medications; he does not smoke; he exercises three times ...

American Family Physician : Putting Prevention into Practice

https://www.aafp.org/afp/2017/1215/p805.html

Statins in Persons at Low Risk of Cardiovascular Disease - Medicine by the Numbers - ...

Nov 1, 2017 - Despite the small reductions in nonfatal heart attacks and strokes, statins were not associated with a reduction in serious illness overall.

American Family Physician : Medicine by the Numbers

https://www.aafp.org/afp/2017/1101/od1.html

Screening for Lipid Disorders in Children and Adolescents - Putting Prevention into ...

Oct 15, 2017 - A healthy 12-year-old boy presents for a school physical and well visit. His family history reveals that his maternal grandfather had a heart attack at 75 years of age and that his 52-year-old father has started taking a medication for elevated cholesterol levels.

American Family Physician : Putting Prevention into Practice

https://www.aafp.org/afp/2017/1015/p529.html

Niacin Does Not Decrease Mortality in Patients with Coronary Artery Disease or Low HDL ...

Jul 15, 2017 - We are now flush with data about the effects of niacin in patients with elevated cholesterol levels. Despite its ability to raise high-density lipoprotein (HDL) serum cholesterol levels, it does not add additional mortality or morbidity benefit to statin treatment. Patients with ...

American Family Physician : POEMs

https://www.aafp.org/afp/2017/0715/p129.html

Hyperlipidemia: Drugs for Cardiovascular Risk Reduction in Adults - American Family ...

Jan 15, 2017 - Guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) and the U.K. National Institute for Health and Care Excellence (NICE) indicate that lipid-lowering drugs have benefit for primary and secondary prevention of atherosclerotic cardiovascular disease ...

American Family Physician : Article

https://www.aafp.org/afp/2017/0115/p78.html

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: ...

Jan 15, 2017 - The USPSTF recommends that adults without a history of cardiovascular disease (CVD) (i.e., symptomatic coronary artery disease or ischemic stroke) use a low- to moderate-dose statin for the prevention of CVD events and mortality when all of the following criteria are met: (1) they are ...

American Family Physician : U.S. Preventive Services Task Force

https://www.aafp.org/afp/2017/0115/od1.html

The Cholesterol Dilemma: Treating the Risk or Treating to LDL-C Goal? - Editorials - ...

Jan 15, 2017 - Statins will long remain the cornerstone of treatment because of their proven benefits and cost-effectiveness, especially in the four statin benefit groups. However, emerging RCT evidence shows that the degree of LDL-C lowering may be more important than the drug used to achieve it.

American Family Physician : Editorials

https://www.aafp.org/afp/2017/0115/p66.html

Screening for Lipid Disorders in Children and Adolescents: Recommendation Statement - ...

Dec 15, 2016 - The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger.

American Family Physician : U.S. Preventive Services Task Force

https://www.aafp.org/afp/2016/1215/od1.html

Evolocumab (Repatha) for the Treatment of Hyperlipidemia - STEPS - American Family ...

Nov 15, 2016 - Evolocumab is generally safe and effective at lowering serum LDL cholesterol levels for select patients who need marked cholesterol reduction and can tolerate injections. However, it remains unknown whether evolocumab prevents premature death from cardiovascular events.

American Family Physician : STEPS

https://www.aafp.org/afp/2016/1115/p843.html

Alirocumab (Praluent) for Treatment of Hyperlipidemia - STEPS - American Family Physician

Aug 15, 2016 - Alirocumab is a novel lipid-lowering therapy that is highly effective at lowering LDL cholesterol when used in addition to statin therapy and diet. Its use should be limited to patients with either heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular ...

American Family Physician : STEPS

https://www.aafp.org/afp/2016/0815/p310.html

ACC/AHA Release Updated Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD...

Aug 15, 2014 - The Blood Cholesterol Expert Panel from the American College of Cardiology (ACC) and the American Heart Association (AHA) issued an updated evidence-based guideline in 2013 that addresses the use of fixed doses of cholesterol-lowering drugs (statins) to reduce the risk of ASCVD in ...

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2014/0815/p260.html

Should Family Physicians Follow the New ACC/AHA Cholesterol Treatment Guideline? Yes: ...

Aug 15, 2014 - The recommendations appropriately focus treatment on those most likely to benefit.

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2014/0815/p212.html

Should Family Physicians Follow the New ACC/AHA Cholesterol Treatment Guideline? Not ...

Aug 15, 2014 - The recommendations should have paid more attention to the inherent uncertainties in risk estimates and the importance of individual patient circumstances and preferences.

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2014/0815/p223.html

Fish Oil for Treatment of Dyslipidemia - FPIN's Clinical Inquiries - American Family ...

Feb 15, 2014 - Supplementation with omega-3 fatty acids decreases triglyceride and very low-density lipoprotein cholesterol levels. However, it can also increase low-density lipoprotein (LDL) cholesterol levels. Treatment with omega-3 fatty acids does not decrease total mortality, cardiovascular ...

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2014/0215/p288.html

Endocrine Society Releases Guidelines on Diagnosis and Management of ...

Jul 15, 2013 - The Endocrine Society recently published evidence-based recommendations on the diagnosis and management of hypertriglyceridemia in adults. Contributing factors include overweight and obesity, physical inactivity, excessive alcohol intake, metabolic syndrome, type 2 diabetes mellitus, ...

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2013/0715/p142.html

NHLBI Expert Panel Releases Guidelines for Cardiovascular Health and Risk Reduction in ...

Oct 15, 2012 - Evidence indicates that reducing risk can slow the progression of cardiovascular disease (CVD); therefore, the National Heart, Lung, and Blood Institute (NHBLI) Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents developed ...

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2012/1015/p776.html

Should Family Physicians Routinely Screen for Hypercholesterolemia in Children? Yes: ...

Oct 15, 2012 - Yes: The Evidence Supports Universal Screening. Atherosclerotic cardiovascular disease events are the culmination of a process that has clearly been shown to begin in childhood, with accumulation of abnormal lipids in the vascular intima.

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2012/1015/od2.html

Editorials: Controversies in Family Medicine - Oct 15, 2012 - American Family Physician

Oct 15, 2012 - No: Universal Screening Has Uncertain Benefits and a High Risk of Harms. Atherosclerosis can be demonstrated in young arteries, and its development over time correlates with the presence of risk factors for the disease, including higher lipid levels. But the presence of this association...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2012/1015/od1.html

Statins for Primary Cardiovascular Prevention - Cochrane for Clinicians - American ...

Oct 1, 2011 - Trials to date have found that statins reduce all-cause mortality, composite cardiovascular outcomes, and revascularization. However, most trials included large numbers of persons with known CVD. Clear evidence of the effectiveness of statins to prevent a first cardiovascular event is ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1001/p767.html

Primary Prevention of CVD: Treating Dyslipidemia - Clinical Evidence Handbook - ...

May 15, 2011 - What are the effects of pharmacologic cholesterol-lowering interventions in persons at low, medium, and high risk of CHD? What are the effects of a reduced- or modified-fat diet in persons at risk of CHD?

American Family Physician : Clinical Evidence Handbook

https://www.aafp.org/afp/2011/0515/p1207.html

Considerations for Safe Use of Statins: Liver Enzyme Abnormalities and Muscle Toxicitiy...

Mar 15, 2011 - Statins play an important role in the care of patients with cardiovascular disease and have a good safety record in clinical practice. The risk of hepatic injury caused by statins is estimated to be about 1 percent, similar to that of patients taking a placebo. Patients with ...

American Family Physician : Article

https://www.aafp.org/afp/2011/0315/p711.html

Should We Treat Moderately Elevated Triglycerides? Yes: Treatment of Moderately ...

Feb 1, 2011 - Advertisement << Previous article Next article >> Feb 1, 2011 Issue Editorials: Controversies in Family Medicine Should We Treat Moderately Elevated Triglycerides? Yes: Treatment of Moderately Elevated Triglycerides Is Supported by the Evidence RADE N. PEJIC, MD, MMM, Tulane...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2011/0201/p242.html

Should We Treat Moderately Elevated Triglycerides? No: Reducing Moderately Elevated ...

Feb 1, 2011 - Moderately elevated triglyceride levels have not been established as an independent risk factor for CHD. More importantly, the lowering of moderately elevated triglyceride levels with drug therapy has not been shown to decrease the rate of CHD for primary prevention in otherwise healthy...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2011/0201/p246.html

The Role of Nonstatin Therapy in Managing Hyperlipidemia - Editorials: Controversies in...

Nov 1, 2010 - When treating hyperlipidemia, physicians often face the question of the clinical value of nonstatin drugs, including bile acid sequestrants, fibrates (fibric acid derivatives), niacin, and cholesterol-absorption inhibitors. This editorial highlights the most prominent trial data and ...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2010/1101/p1056.html

For Hyperlipidemia, Go Where the Evidence Takes You: Give a Statin and Nothing Else - ...

Nov 1, 2010 - Only statins have patient-oriented evidence supporting their role in reducing all-cause mortality. The NCEP–ATP III guidelines offer a nine-step approach for reaching target lipid levels, but the application to everyday practice is far simpler: If a patient with hyperlipidemia has ...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2010/1101/p1063.html

Hyperlipidemia Treatment in Children: The Younger, the Better - Editorials: ...

Sep 1, 2010 - Despite the absence of data in children demonstrating morbidity and mortality reduction by aggressive treatment of lipid disorders, the overwhelming data in adults (e.g., decreasing LDL cholesterol, improved morbidity and mortality) and evidence of atherosclerotic lesions developing in ...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2010/0901/p460.html

Screening for Hyperlipidemia in Children: Primum Non Nocere - Editorials: Controversies...

Sep 1, 2010 - Only 40 to 55 percent of children with elevated cholesterol and low-density lipoprotein levels will continue to have elevated lipids on follow-up. A recent evidence review supporting the U.S. Preventive Services Task Force statement on lipid screening in children reached the following ...

American Family Physician : Editorials: Controversies in Family Medicine

https://www.aafp.org/afp/2010/0901/p468.html

Diet and Exercise in the Management of Hyperlipidemia - American Family Physician

May 1, 2010 - Dietary factors that influence lipid levels include modification of nutritional components, consumption of specific foods, use of food additives and supplements, and major dietary approaches. The most beneficial changes result from reducing intake of saturated and trans fats; increasing...

American Family Physician : Article

https://www.aafp.org/afp/2010/0501/p1097.html

Statins for Non-Dialysis Chronic Kidney Disease - Cochrane for Clinicians - American ...

Jan 1, 2010 - When taken over a five-year period, statins significantly reduce all-cause mortality (number needed to treat [NNT] = 56), cardiovascular mortality (NNT = 86), and nonfatal cardiovascular events (NNT = 25).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0101/p27.html

Screening for Lipid Disorders in Adults: Recommendation Statement - U.S. Preventive ...

Dec 1, 2009 - Screening men: The U.S. Preventive Services Task Force (USPSTF) strongly recommends screening men 35 years and older for lipid disorders.

American Family Physician : U.S. Preventive Services Task Force

https://www.aafp.org/afp/2009/1201/p1273.html

Screening for Lipid Disorders in Adults - Putting Prevention into Practice - American ...

Dec 1, 2009 - Case study: E.B. is a 50-year-old black woman who comes to your office for weight-loss counseling. She reports that her brother recently had a heart attack at 58 years of age. She does not smoke and takes no medications other than a daily multivitamin.

American Family Physician : Putting Prevention into Practice

https://www.aafp.org/afp/2009/1201/p1281.html

AAP Clinical Report on Lipid Screening in Children - Practice Guidelines - American ...

Apr 15, 2009 - The American Academy of Pediatrics (AAP) released a clinical report in July 2008 that recommends lipid screening in children and adolescents with a fasting lipid profile, and focuses on improving childhood and adolescent lipid and lipoprotein concentrations to lower the lifetime risk of...

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2009/0415/p703.html

The JUPITER Study: Biomarkers Plus Statin vs. Lifestyle Modification for Preventing ...

Mar 15, 2009 - Advertisement << Previous article Next article >> Mar 15, 2009 Issue Editorials The JUPITER Study: Biomarkers Plus Statin vs. Lifestyle Modification for Preventing Cardiovascular Events COLIN KOPES-KERR, MD, Santa Rosa Family Medicine Residency, Santa Rosa, California MARK EBELL, MD,...

American Family Physician : Editorials

https://www.aafp.org/afp/2009/0315/p438.html

AHA Publishes Statement on Drug Therapy for Lipid Abnormalities in Children and ...

Mar 1, 2008 - The American Heart Association (AHA) has published a scientific statement on drug therapy for the treatment of high-risk lipid abnormalities in children and adolescents.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2008/0301/p694.html

Lessons from Torcetrapib: Putting Patient-Oriented Evidence First - Editorials - ...

Mar 1, 2008 - Advertisement << Previous article Next article >> Mar 1, 2008 Issue Editorials Lessons from Torcetrapib: Putting Patient-Oriented Evidence First ROBERT M. EWART, MD, Southern Illinois University School of Medicine, Springfield, Illinois Am Fam Physician. 2008 Mar 1;77(5):597-598. The...

American Family Physician : Editorials

https://www.aafp.org/afp/2008/0301/p597.html

Best Alternatives to Statins for Treating Hyperlipidemia - FPIN's Clinical Inquiries - ...

Oct 1, 2007 - Most alternatives to statin therapy reduce cholesterol levels but do not consistently demonstrate a reduction in cardiac-related and all-cause mortality in patients with or without coronary heart disease (CHD). Fibrates and niacin decrease the risk of major coronary events; however, no ...

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2007/1001/p1027.html

U.S. Statin Guidelines: Expensive but Not Necessarily Effective - Editorials - American...

May 15, 2007 - Advertisement << Previous article Next article >> May 15, 2007 Issue Editorials U.S. Statin Guidelines: Expensive but Not Necessarily Effective HENRY C. BARRY, MD, MS, Michigan State University College of Human Medicine, East Lansing, Michigan JEROME R. HOFFMAN, MD, MA, David Geffen...

American Family Physician : Editorials

https://www.aafp.org/afp/2007/0515/p1453.html

Management of Hypertriglyceridemia - American Family Physician

May 1, 2007 - Hypertriglyceridemia is associated with an increased risk of cardiovascular events and acute pancreatitis. Along with lowering low-density lipoprotein cholesterol levels and raising high-density lipoprotein cholesterol levels, lowering triglyceride levels in high-risk patients (e.g., ...

American Family Physician : Article

https://www.aafp.org/afp/2007/0501/p1365.html

Which Lipoprotein Measurements Are Clinically Useful? - FPIN's Clinical Inquiries - ...

Feb 1, 2007 - Emerging lipid risk factors for cardiovascular disease include lipoprotein remnants, lipoprotein (a), small LDL particles, HDL subspecies, apolipoprotein B, apolipoprotein A-I, and oxidized LDL. Measurement of these levels should not be used for routine cardiovascular risk screening.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2007/0201/p387.html

AHA and NHLBI Review Diagnosis and Management of the Metabolic Syndrome - Practice ...

Sep 15, 2006 - The American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) have released joint recommendations on the management and diagnosis of the metabolic syndrome.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2006/0915/p1039.html

Practice Guidelines - Apr 1, 2006 - American Family Physician

Apr 1, 2006 - The American Academy of Neurology (AAN) has released evidence-based recommendations for the use of serum prolactin tests in differentiating between epileptic and nonepileptic seizures.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2006/0401/p1284.html

Practice Guidelines - Apr 1, 2006 - American Family Physician

Apr 1, 2006 - The Centers for Disease Control and Prevention (CDC) has published a report on the prevalence of cholesterol screening and awareness using data from the Behavioral Risk Factor Surveillance System.

American Family Physician : Practice Guidelines

https://www.aafp.org/afp/2006/0401/p1284a.html

Amlodipine/Atorvastin (Caduet) for Preventing Heart Disease - STEPS - American Family ...

Mar 15, 2006 - Amlodipine/atorvastatin offers no added benefit in safety, tolerability, or effectiveness over amlodipine and atorvastatin taken separately. It has not been shown to improve mortality or morbidity in patients who have hypertension with or without dyslipidemia. The only potential ...

American Family Physician : STEPS

https://www.aafp.org/afp/2006/0315/p1067.html

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