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Pharmacologic Interventions for Apathy in Patients with Alzheimer Disease - Cochrane ...

Jan 1, 2019 - Methylphenidate may improve apathy in select patients with AD (mean difference [MD] = –4.99 on the apathy evaluation scale; 95% confidence interval [CI], –9.55 to –0.43), although the clinical significance associated with these findings remains unclear and the evidence is considered low...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0101/p14.html

Cerebrospinal Fluid Biomarkers for Detection of Alzheimer Disease in Patients with Mild...

Jun 1, 2018 - There is insufficient evidence to support the routine use of cerebrospinal fluid (CSF) biomarkers for the detection of progressive dementias in patients with mild cognitive impairment (MCI). These tests carry the risk of overdiagnosis of dementia and, therefore, overtreatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0601/p714.html

Mini-Mental State Examination for the Detection of Dementia in Older Patients - ...

Dec 1, 2016 - When scores are adjusted based on a patient's education level, the MMSE may be useful to rule out a diagnosis of dementia in clinically unevaluated patients 65 years and older (sensitivity = 97%; specificity = 70%). Scores of less than 24 may also be useful to rule in dementia in ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/1201/p880.html

The Effect of Statins on Dementia and Cognitive Decline - Cochrane for Clinicians - ...

Feb 1, 2017 - Statins given in later life to patients at risk of vascular disease do not prevent dementia or cognitive decline compared with placebo. Adverse effects are similar between groups.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0201/p151.html

Exercise Programs for Older Patients with Dementia - Cochrane for Clinicians - American...

Sep 1, 2014 - There is some evidence that exercise improves cognitive function and the ability to perform activities of daily living in patients with dementia.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2014/0901/p287.html

Antidepressants for Agitation and Psychosis in Patients with Dementia - Cochrane for ...

Jan 1, 2012 - There are few high-quality studies examining the effectiveness of antidepressants for treating the neuropsychiatric symptoms of dementia. Although there is some evidence to support the use of the selective serotonin reuptake inhibitors (SSRIs) sertraline (Zoloft) and citalopram ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2012/0101/p20.html

Cognitive Interventions for Improving Cognitive Function - Cochrane for Clinicians - ...

Nov 1, 2011 - Compared with no treatment, cognitive interventions improved cognitive performance in healthy older adults and older adults with mild cognitive impairments. However, there is inadequate evidence to determine which aspects of these interventions are effective.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1101/p992.html

Aerobic Activity for Cognitive Function - Cochrane for Clinicians - American Family ...

Apr 1, 2009 - Physical activity improves cardiovascular fitness in persons older than 55 years. Cognitive speed and auditory and visual attention are increased in healthy older adults who exercise.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2009/0401/p562.html

Cholinesterase Inhibitors for Alzheimer's Disease - Cochrane for Clinicians - American ...

Sep 1, 2006 - Cholinesterase inhibitors produce a small benefit on several cognitive and noncognitive function scales. Although data for patients with severe dementia are sparse, there is no evidence to suggest a difference in effectiveness among patients with mild, moderate, or severe dementia. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0901/p747.html

Are Atypical Antipsychotics Safe in Patients with Alzheimer's Disease? - Cochrane for ...

Aug 1, 2006 - Although the atypical antipsychotic medications risperidone (Risperdal) and olanzapine (Zyprexa) are modestly efficacious in reducing aggression, routine use is not justified. Both drugs are associated with serious adverse cerebrovascular events and extrapyramidal symptoms. Use of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0801/p414.html

Donepezil in the Treatment of Vascular Dementia - Cochrane for Clinicians - American ...

Nov 1, 2004 - Donepezil in a dosage of 10 mg daily provides a small benefit in patients with mild to moderate vascular dementia and generally is well tolerated.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1101/p1681.html

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