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Diabetic Kidney Disease: Diagnosis, Treatment, and Prevention - American Family Physician

Jun 15, 2019 - Globally, approximately 20% of the 400 million individuals with diabetes mellitus have diabetic kidney disease (DKD). DKD is associated with higher cardiovascular and all-cause morbidity and mortality, so timely diagnosis and treatment are critical. Screening for early DKD is best done ...

American Family Physician : Article

https://www.aafp.org/afp/2019/0615/p751.html

Chronic Kidney Disease: Detection and Evaluation - American Family Physician

Dec 15, 2017 - Chronic kidney disease affects 47 million people in the United States and is associated with significant health care costs, morbidity, and mortality. Because this disease can silently progress to advanced stages, early detection is critical for initiating timely interventions. Multiple ...

American Family Physician : Article

https://www.aafp.org/afp/2017/1215/p776.html

Proteinuria in Children: Evaluation and Differential Diagnosis - American Family Physician

Feb 15, 2017 - Although proteinuria is usually benign in the form of transient or orthostatic proteinuria, persistent proteinuria may be associated with more serious renal diseases. Proteinuria may be an independent risk factor for the progression of chronic kidney disease in children. Mechanisms of ...

American Family Physician : Article

https://www.aafp.org/afp/2017/0215/p248.html

Diabetic Nephropathy--The Family Physician's Role - American Family Physician

May 1, 2012 - Nearly one-half of persons with chronic kidney disease have diabetes mellitus. Diabetes accounted for 44 percent of new cases of kidney failure in 2008. Diabetic nephropathy, also called diabetic kidney disease, is associated with significant macrovascular risk, and is the leading cause...

American Family Physician : Article

https://www.aafp.org/afp/2012/0501/p883.html

Autosomal Dominant Polycystic Kidney Disease - American Family Physician

Sep 1, 2014 - Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney disease. Enlarging cysts within the kidneys are the clinical hallmark of the disease. Renal manifestations include varying degrees of kidney injury, urinary tract infections, kidney stones,...

American Family Physician : Article

https://www.aafp.org/afp/2014/0901/p303.html

Urinalysis: A Comprehensive Review - American Family Physician

Mar 15, 2005 - A complete urinalysis includes physical, chemical, and microscopic examinations. Midstream clean collection is acceptable in most situations, but the specimen should be examined within two hours of collection. Cloudy urine often is a result of precipitated phosphate crystals in alkaline...

American Family Physician : Article

https://www.aafp.org/afp/2005/0315/p1153.html

End-Stage Renal Disease: Symptom Management and Advance Care Planning - American Family...

Apr 1, 2012 - The prevalence of end-stage renal disease continues to increase, and dialysis is offered to older and more medically complex patients. Pain is problematic in up to one-half of patients receiving dialysis and may result from renal and nonrenal etiologies. Opioids can be prescribed ...

American Family Physician : Article

https://www.aafp.org/afp/2012/0401/p705.html

Nephrotic Syndrome in Adults: Diagnosis and Management - American Family Physician

Nov 15, 2009 - Nephrotic syndrome may be caused by primary (idiopathic) renal disease or by a variety of secondary causes. Patients present with marked edema, proteinuria, hypoalbuminemia, and often hyperlipidemia. In adults, diabetes mellitus is the most common secondary cause, and focal segmental ...

American Family Physician : Article

https://www.aafp.org/afp/2009/1115/p1129.html

Proteinuria in Children - American Family Physician

Sep 15, 2010 - Proteinuria is common in children and may represent a benign condition or a serious underlying renal disease or systemic disorder. Proteinuria may occur secondary to glomerular or tubular dysfunction. Although a 24-hour urine protein excretion test is usually recommended, it may be ...

American Family Physician : Article

https://www.aafp.org/afp/2010/0915/p645.html

Diagnosis and Management of Acute Interstitial Nephritis - American Family Physician

Jun 15, 2003 - Acute interstitial nephritis is an important cause of acute renal failure resulting from immune-mediated tubulointerstitial injury, initiated by medications, infection, and other causes. Acute interstitial nephritis may be implicated in up to 15 percent of patients hospitalized for ...

American Family Physician : Article

https://www.aafp.org/afp/2003/0615/p2527.html

Evaluation of Poststreptococcal Illness - American Family Physician

May 15, 2005 - Group A beta-hemolytic streptococcal pharyngitis, scarlet fever, and rarely asymptomatic carrier states are associated with a number of poststreptococcal suppurative and nonsuppurative complications. As in streptococcal pharyngitis, acute rheumatic fever, pediatric autoimmune ...

American Family Physician : Article

https://www.aafp.org/afp/2005/0515/p1949.html

Detection and Evaluation of Chronic Kidney Disease - American Family Physician

Nov 1, 2005 - Chronic kidney disease affects approximately 19 million adult Americans, and its incidence is increasing rapidly. Diabetes and hypertension are the underlying causes in most cases of chronic kidney disease. Evidence suggests that progression to kidney failure can be delayed or prevented...

American Family Physician : Article

https://www.aafp.org/afp/2005/1101/p1723.html

Hemolytic Uremic Syndrome: An Emerging Health Risk - American Family Physician

Sep 15, 2006 - Hemolytic uremic syndrome is caused primarily by Shiga toxin-producing Escherichia coli O157:H7. The most common cause of acute renal failure in children, hemolytic uremic syndrome also can occur in adults. Characteristic features of the syndrome are microangiopathic anemia, thrombotic ...

American Family Physician : Article

https://www.aafp.org/afp/2006/0915/p991.html

Management of Acute Renal Failure - American Family Physician

Nov 1, 2005 - Acute renal failure is present in 1 to 5 percent of patients at hospital admission and affects up to 20 percent of patients in intensive care units. The condition has prerenal, intrarenal, and postrenal causes, with prerenal conditions accounting for 60 to 70 percent of cases. The cause...

American Family Physician : Article

https://www.aafp.org/afp/2005/1101/p1739.html

Clinical Practice Guidelines for Chronic Kidney Disease in Adults: Part 1. Definition, ...

Sep 1, 2004 - In February 2002, the Kidney Disease Outcome Quality Initiative of the National Kidney Foundation published clinical practice guidelines on chronic kidney disease. The first six of the 15 guidelines are of the greatest relevance to family physicians. Part I of this two-part article ...

American Family Physician : Article

https://www.aafp.org/afp/2004/0901/p869.html

ACE Inhibitors or ARBs to Prevent CKD in Patients with Microalbuminuria - FPIN's ...

Oct 15, 2016 - ACE inhibitors reduce the risk of progression to macroalbuminuria in normotensive patients with microalbuminuria and type 1 diabetes mellitus.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2016/1015/p652.html

Preoperative Care of Patients with Kidney Disease - American Family Physician

Oct 15, 2002 - Patients with chronic kidney disease often require surgical interventions for vascular access and for medical problems related to comorbid conditions. Perioperative morbidity and mortality rates are increased in these patients. Preoperative attention to common medical problems that ...

American Family Physician : Article

https://www.aafp.org/afp/2002/1015/p1471.html

Clinical Practice Guidelines for Chronic Kidney Disease in Adults: Part II. Glomerular ...

Sep 15, 2004 - The Kidney Disease Outcome Quality Initiative of the National Kidney Foundation published clinical practice guidelines on chronic kidney disease in February 2002. Of the 15 guidelines, the first six are of greatest relevance to family physicians. Part II of this two-part review covers ...

American Family Physician : Article

https://www.aafp.org/afp/2004/0915/p1091.html

Effects of Altered Dietary Salt Intake in Patients with Chronic Kidney Disease - ...

Apr 1, 2017 - Reducing salt intake lowers blood pressure and reduces proteinuria in patients with CKD, but there is no evidence to determine whether lowering salt consumption leads to clinically significant reductions in end-stage renal disease, cardiovascular events, or all-cause mortality.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0401/p423.html

Evaluating Proteinuria in Children - American Family Physician

Oct 1, 1998 - Proteinuria is a common laboratory finding in children. It can be identified as either a transient or a persistent finding and can represent a benign condition or a serious disease. A rapid but qualitative assessment of proteinuria can be made using dipstick or sulfosalicylic acid ...

American Family Physician : Article

https://www.aafp.org/afp/1998/1001/p1145.html

Screening for Chronic Kidney Disease - Putting Prevention into Practice - American ...

Feb 15, 2014 - A 55-year-old woman with no history of diabetes mellitus or hypertension asks to be screened for chronic kidney disease (CKD). Her 88-year-old mother has end-stage renal disease and is currently undergoing renal dialysis. The patient says she wants to take all necessary precautions to ...

American Family Physician : Putting Prevention into Practice

https://www.aafp.org/afp/2014/0215/p293.html

Intensive Blood Pressure Control in Older Patients Can Decrease Renal Function - POEMs ...

Jan 1, 2018 - In this post-hoc analysis of the previously published SPRINT trial, lowering the systolic blood pressure of patients who are at increased risk of cardiovascular events (average age = 66 years) will decrease their risk of cardiovascular disease but increase their likelihood of developing...

American Family Physician : POEMs

https://www.aafp.org/afp/2018/0101/p54.html

Statins for Non-Dialysis Chronic Kidney Disease - Cochrane for Clinicians - American ...

Jan 1, 2010 - When taken over a five-year period, statins significantly reduce all-cause mortality (number needed to treat [NNT] = 56), cardiovascular mortality (NNT = 86), and nonfatal cardiovascular events (NNT = 25).

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2010/0101/p27.html

Antihypertensive Agents for Prevention of Diabetic Nephropathy - Cochrane for ...

Jul 1, 2006 - Angiotensin-converting enzyme (ACE) inhibitors are the only antihypertensive agents with proven effectiveness for the primary prevention of diabetic nephropathy (defined as an albumin excretion of less than 30 mg per day on three serial measurements) caused by type 1 or type 2 diabetes....

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/0701/p77.html

ACE Inhibitors vs. ARBs for Patients with Diabetic Kidney Disease - Cochrane for ...

Jul 1, 2007 - Studies comparing ACE inhibitors or ARBs with placebo found no mortality benefit in patients with diabetic kidney disease. A subgroup analysis of five studies (2,034 total patients) found that, when given at full or maximally tolerated doses, ACE inhibitors reduce all-cause mortality ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0701/p68.html

Angiotensin Blockade in Patients with Diabetic Nephropathy - FPIN's Clinical Inquiries ...

Aug 1, 2007 - When used to delay the progression of early nephropathy in patients with type 2 diabetes mellitus, angiotensin receptor blockers (ARBs) are not superior to angiotensin-converting enzyme (ACE) inhibitors.

American Family Physician : FPIN's Clinical Inquiries

https://www.aafp.org/afp/2007/0801/p423.html

ACE Inhibitor Therapy: Benefits and Underuse - Editorials - American Family Physician

Jan 1, 1999 - ...SIDNEY C. SMITH, JR., M.D., University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina Am Fam Physician. 1999 Jan 1;59(1):35-. During the past decade, several landmark trials have confirmed the benefits of angiotensin converting enzyme (ACE)...

American Family Physician : Editorials

https://www.aafp.org/afp/1999/0101/p35.html

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