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Medicine by the numbers

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Prophylactic Vaccination Against Human Papillomavirus to Prevent Cervical Cancer and ...

Jan 1, 2019 - HPV vaccination in women 15 to 26 years of age prevents the development of cervical intraepithelial neoplasia (CIN) 2 and CIN 3 in women regardless of previous HPV exposure (number needed to treat [NNT] = 39). No serious adverse effects are associated with administration of the HPV ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0101/p15.html

Preventing or Delaying Type 2 Diabetes Mellitus with Diet and Exercise - Cochrane for ...

Dec 1, 2018 - There is moderate-quality evidence that in patients with impaired glucose tolerance (IGT) defined by an abnormal 75-g two-hour glucose tolerance test, implementing changes in diet and adding physical activity together can prevent or delay the development of type 2 diabetes.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/1201/p643.html

Individual Behavioral Counseling for Smoking Cessation - Cochrane for Clinicians - ...

Jul 1, 2018 - Individual behavioral counseling conducted by a trained therapist provides some benefit when compared with brief counseling and support; however, this benefit is less pronounced in the context of pharmacotherapy.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0701/p21.html

Vaccines for Preventing Influenza in Healthy Children, Healthy Adults, and Older Adults...

Aug 1, 2019 - Influenza vaccination reduces rates of laboratory-confirmed influenza and symptomatic influenza-like illness in healthy children, healthy adults, and older adults. There is no consistent evidence that influenza vaccination reduces school absenteeism in children, parental absenteeism ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2019/0801/p143.html

Interventions for Preventing Falls Among Older Adults Living in the Community - ...

Feb 1, 2017 - Structured exercise programs and home safety interventions reduce both the rate and the risk of falling among community-dwelling adults 65 years and older, whereas multifactorial assessment and intervention programs reduce the rate of falls but not the risk of falling. Vitamin D ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2017/0201/p152.html

Influenza Vaccination for the Prevention of Cardiovascular Disease - Cochrane for ...

Mar 1, 2016 - Influenza vaccination may reduce cardiovascular mortality in patients with established cardiovascular disease. The effect of vaccination is unclear among patients in the general population without known cardiovascular disease.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0301/p357.html

Cerebrospinal Fluid Biomarkers for Detection of Alzheimer Disease in Patients with Mild...

Jun 1, 2018 - There is insufficient evidence to support the routine use of cerebrospinal fluid (CSF) biomarkers for the detection of progressive dementias in patients with mild cognitive impairment (MCI). These tests carry the risk of overdiagnosis of dementia and, therefore, overtreatment.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2018/0601/p714.html

Dietary Fat Modification and the Risk of Future Cardiovascular Events and Mortality - ...

May 1, 2013 - According to the authors of this Cochrane review, reducing or modifying a patient's dietary fat intake did not lower the rates of either total or cardiovascular-related mortality when compared with usual or control diets. Reducing the intake of total or saturated fats decreased the risk...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0501/p609.html

Interventions Aimed at Increasing Childhood Vaccination Rates - Cochrane for Clinicians...

Nov 1, 2015 - Community discussions, community meetings, and information campaigns may increase immunization uptake in areas with only moderate vaccine use. There is no clear evidence to guide face-to-face educational interventions, and the impact of face-to-face interventions is uncertain in areas ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2015/1101/p775.html

General Health Checks for Reducing Morbidity and Mortality - Cochrane for Clinicians - ...

Oct 1, 2013 - Although general health checks increase the number of new diagnoses, they do not decrease total, cardiovascular-related, or cancer-related morbidity or mortality. The studies in this Cochrane review have limited applicability to the current recommended practice of providing selective, ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1001/p432.html

Fluoride Varnish for Preventing Dental Caries in Children and Adolescents - Cochrane ...

May 1, 2016 - Topically applied fluoride varnishes are safe and effective in preventing dental caries in children and adolescents. There is little information about adverse effects or treatment acceptability. Family physicians should consider incorporating fluoride varnish into childhood preventive ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2016/0501/p743.html

Antiretroviral Preexposure Prophylaxis for Preventing HIV Infection in High-Risk ...

Aug 1, 2013 - For some groups of patients at greater risk of HIV infection (e.g., serodiscordant partners, men who have sex with men and engage in high-risk behaviors, persons with multiple concurrent sex partners, persons who exchange sex for money), preexposure prophylaxis decreased the risk of ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/0801/p172.html

Prevention of Herpes Zoster in Older Adults - Cochrane for Clinicians - American Family...

Nov 1, 2013 - The herpes zoster (shingles) vaccine has demonstrated effectiveness in preventing shingles in older adults. Vaccination benefit was greater in persons 60 to 69 years of age than in those 70 years and older. Local injection site reactions were common.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2013/1101/p578.html

Effect of Mammography on Breast Cancer Mortality - Cochrane for Clinicians - American ...

Dec 1, 2011 - Although mammography can lead to false-positive results, emotional stress, and unnecessary biopsies, it appears to reduce deaths from breast cancer by about 15 percent.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2011/1201/p1225.html

Alendronate for Fracture Prevention in Postmenopause - Cochrane for Clinicians - ...

Sep 1, 2008 - In postmenopausal women, a 10-mg daily dose of alendronate is effective for secondary (number needed to treat [NNT] = 16) and primary (NNT = 50) prevention of vertebral fractures. It is also effective for secondary prevention of nonvertebral fractures, including hip or wrist fractures ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2008/0901/p579.html

Counseling Women About Mammography: Benefits vs. Harms - Cochrane for Clinicians - ...

Sep 1, 2007 - Studies of mammography show a 0.1 percent absolute reduction in breast cancer mortality with mammography. This means that if 2,000 women are offered mammography over 10 years, one woman would have her life prolonged, 10 healthy women would be treated unnecessarily for breast cancer, and...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0901/p652.html

Exercise is an Effective Intervention in Overweight and Obese Patients - Cochrane for ...

May 1, 2007 - Exercise leads to a weight loss of 1 lb, 2 oz to 16 lb, 12 oz (0.5 to 7.6 kg), compared with a 3-oz (0.1-kg) weight loss to a weight gain of 1 lb, 9 oz (0.7 kg) with no treatment. Patients participating in higher-intensity exercise lose 3 lb, 5 oz (1.5 kg) more than those participating ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2007/0501/p1333.html

Calcium Supplementation in Postmenopausal Women - Cochrane for Clinicians - American ...

Jun 15, 2004 - Calcium supplementation has a beneficial effect on bone density and may reduce vertebral fractures. It has no clear effect on nonvertebral fractures, although the number of patients studied may be too small to predict this outcome.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/0615/p2822.html

Effectiveness of Condoms in Reducing Heterosexual Transmission of HIV - Cochrane for ...

Oct 1, 2004 - Evidence indicates that male condoms reduce the risk of heterosexual HIV transmission by 80 percent.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2004/1001/p1268.html

Should We Use Multiple Risk Factor Interventions for the Primary Prevention of Coronary...

Jul 15, 2002 - In hypertensive patients at high risk for coronary artery disease, multiple risk factor reduction interventions reduce risk factors and mortality. In other patients, multiple risk factor reduction interventions reduce total cholesterol levels, blood pressure (systolic and diastolic) ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2002/0715/p245.html

Vaccines for Preventing Influenza in Healthy Children - Cochrane for Clinicians - ...

Oct 1, 2006 - Influenza vaccines have good efficacy (i.e., prevention of influenza) in children older than two years, and live, attenuated vaccine is more efficacious than trivalent, inactivated vaccine. Effectiveness (i.e., prevention of influenza-like illness, perhaps a clinically more important ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2006/1001/p1123.html

Can Reduced or Modified Dietary Fat Prevent Cardiovascular Disease? - Cochrane for ...

Jan 1, 2002 - Reducing or modifying the amount or type of fat in a patient's diet and replacing it with polyunsaturated fats will not significantly reduce the risk of death from all causes of cardiovascular disease but could reduce the risk of an important cardiovascular disease event by 16 percent. ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2002/0101/p53.html

Should We Offer Routine Breast Cancer Screening with Mammography? - Cochrane for ...

Jul 15, 2003 - While there is good evidence that mammography starting at age 50 reduces breast cancer mortality, this meta-analysis does not provide evidence of a mortality benefit for mammography screening in women aged 40 to 49. Controversy exists over whether to include in the analysis trials with ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/0715/p260.html

Are Low-Fat Diets Better than Other Weight-Reducing Diets in Achieving Long-Term Weight...

Feb 1, 2003 - Low-fat diets are no better than low-calorie diets in achieving weight loss in overweight or obese people. In studies, the average weight loss after 18 months on either diet was less than 5 lb.

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2003/0201/p507.html

Should We Recommend Nicotine Replacement Therapy? - Cochrane for Clinicians - American ...

Jun 1, 2001 - Yes. The patient is highly nicotine-dependent, and for smokers with moderate to severe nicotine dependence, nicotine replacement therapy with or without bupropion should be offered as part of an intensive program of physician advice, counseling and follow-up. This answer is based on an ...

American Family Physician : Cochrane for Clinicians

https://www.aafp.org/afp/2001/0601/p2245.html

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